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ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Proteolytic Cleavage of Molecules Involved in Cell Death or Survival Pathways: A Role in the Control of Apoptosis?

卷 11, 册 4, 2001, 10 pages
DOI: 10.1615/CritRevEukarGeneExpr.v11.i4.10
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摘要

Proteolytic modification of certain key regulatory molecules involved in apoptotic and prosurvival pathways may be a feature of the control of programmed cell death. Four molecules of the Bcl-2 family (BID, Bcl-2, Bax, Bcl-XL) have been reported to be cleaved during apoptosis, as has a cellular inhibitor of apoptosis (XIAP). Two proteins involved in NF-kB activation, RIP and TRAF1, are cleaved during apoptosis induced by agents that activate both pathways. MEKK1, a molecule involved in a protein kinase stress signaling cascade that contributes to apoptosis and NF-kB activation, also undergoes cleavage. In each case, the cleavage products may result in the inactivation of a former function or the gaining of a new function, thus contributing to the delicately balanced regulation of apoptosis.

对本文的引用
  1. Salvesen Guy S., Caspases: Cell Signaling by Proteolysis, in Handbook of Cell Signaling, 2003. Crossref

  2. Roman Dacian, Yasmeen Amber, Mireuta Matei, Stiharu Ion, Al Moustafa Ala-Eddin, Significant toxic role for single-walled carbon nanotubes during normal embryogenesis, Nanomedicine: Nanotechnology, Biology and Medicine, 9, 7, 2013. Crossref

  3. Zhu Daming, Wu Xuan, Strauss Kenneth I., Lipsky Robert H., Qureshi Zehra, Terhakopian Artin, Novelli Antonello, Banaudha Krishna, Marini Ann M., N-methyl-D-aspartate and TrkB receptors protect neurons against glutamate excitotoxicity through an extracellular signal-regulated kinase pathway, Journal of Neuroscience Research, 80, 1, 2005. Crossref

  4. Voth Daniel E., Ballard Jimmy D., Critical intermediate steps in Clostridium sordellii lethal toxin-induced apoptosis, Biochemical and Biophysical Research Communications, 363, 4, 2007. Crossref

  5. Ganesh Subramaniam, Tsurutani Naomi, Amano Kenji, Mittal Shuchi, Uchikawa Chiharu, Delgado-Escueta Antonio V., Yamakawa Kazuhiro, Transcriptional profiling of a mouse model for Lafora disease reveals dysregulation of genes involved in the expression and modification of proteins, Neuroscience Letters, 387, 2, 2005. Crossref

  6. Virador Victoria M., Davidson Ben, Czechowicz Josephine, Mai Alisha, Kassis Jareer, Kohn Elise C., Feng Yue, The Anti-Apoptotic Activity of BAG3 Is Restricted by Caspases and the Proteasome, PLoS ONE, 4, 4, 2009. Crossref

  7. Ding Yi-Shan, Kim Won-Suk, Park Sun Joo, Kim Se-Kwon, Apoptotic effect of physcion isolated from marine fungus Microsporum sp. in PC3 human prostate cancer cells, Fisheries and Aquatic Sciences, 21, 1, 2018. Crossref

  8. Sirotkin A., Kádasi A., Maruniakova N., Grossmann R., Alwasel S., Harrath A., Influence of green tea constituents on cultured porcine luteinized granulosa cell functions, Journal of Animal and Feed Sciences, 28, 1, 2019. Crossref

  9. Liston Peter, Fong Wai Gin, Korneluk Robert G, The inhibitors of apoptosis: there is more to life than Bcl2, Oncogene, 22, 53, 2003. Crossref

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