图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
真核基因表达评论综述™
影响因子: 1.841 5年影响因子: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukarGeneExpr.v20.i2.70
pages 171-180

Circulating Osteogenic Precursor Cells

Robert Pignolo
Departments of Medicine and Orthopaedic Surgery, University of Pennsylvania, School of Medicine
Eileen M. Shore
Departments Orthopaedic Surgery, and Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania

ABSTRACT

Circulating osteogenic precursor (COP) cells are blood-borne cells that express a variety of osteoblastic markers and are able to form bone in vivo. Strong evidence suggests that COP cells are derived from bone marrow and are of hematopoietic origin. The study of COP cells has been limited by several factors, including the difficulty in establishing long-term cultures and lack of a standardized protocol for their isolation and identification. However, experimental evidence supports that COP cells seed sites of injury and inflammation in response to homing signals and are involved in processes of pubertal growth, fracture, and diverse conditions of heterotopic bone formation. The role of COP cells in physiologic and pathophysiologic conditions of de novo bone formation suggests that they may serve as future targets for diagnostic measurements and therapeutic interventions.


Articles with similar content:

The Role of Cytokines and Growth Factors as Mediators of the Effects of Systemic Hormones at the Bone Local Level
Critical Reviews™ in Eukaryotic Gene Expression, Vol.5, 1995, issue 3-4
Gregory R. Mundy, Jose A. Riancho
The Interactions between Bone Remodelling, Estrogen Hormone and EPH Family Genes
Critical Reviews™ in Eukaryotic Gene Expression, Vol.28, 2018, issue 2
Rasime Kalkan, Pinar Tulay
Dyspnoea and Disability: An Epidemiological Approach
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.9, 1997, issue 3-4
Jean-Francois Tessier, Pascale Barberger-Gateau, Chakib Nejjari
Regulation of Dendritic- and T-Cell Fate by Injury-Associated Endogenous Signals
Critical Reviews™ in Immunology, Vol.29, 2009, issue 1
Marco E. Bianchi, Annalisa Capobianco, Angelo A. Manfredi, Patrizia Rovere-Querini
Emerging Roles of CCCH-Type Zinc Finger Proteins in Destabilizing mRNA Encoding Inflammatory Factors and Regulating Immune Responses
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 1
Shaofei Huang, Chuanbin Yang, Yong Gu, Xuanbin Wang