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真核基因表达评论综述™
影响因子: 1.841 5年影响因子: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukaryotGeneExpr.v26.i1.40
pages 27-39

The Route to HPV-Associated Neoplastic Transformation: A Review of the Literature

Pinar Tulay
Near East University
Nedime Serakinci
Near East University, Faculty of Medicine, Department of Medical Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus; Near East University, Faculty of Arts and Sciences, Dept. of Molecular Biology and Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus

ABSTRACT

Human papillomaviruses (HPVs)−small, nonenveloped viruses with double-stranded circular DNA−are believed to have a role in the progression of cancer. However, the exact mechanisms are not well established. The interference of HPV proteins, especially E6 and E7, in the cell cycle is considered to be the main pathway. It is still questioned whether the expression of these proteins or the viral load is more important in neoplastic transformation. Furthermore, HPV is believed to adapt mechanisms to evade the host cell immune system; persistent HPV infection may also play a role in oncogenic transformation by causing genomic instability and local immune suppression. These factors may cause accumulation of genomic alterations within the host cell and integration of the viral genome into the host genome. In recent years, epigenetic modifications, such as methylation, have also been considered to take part in neoplastic transformation. All of these alterations to the genome may be favorable to the development of cancer. This article highlights the association of HPV in neoplastic transformation and cancer progression.


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