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ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

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DOI: 10.1615/CritRevEukaryotGeneExpr.v15.i2.30
pages 115-132

PTHrP Gene Expression in Cancer: Do All Paths Lead to Ets?

Virgile Richard
The Ohio State University Department of Veterinary Biosciences, Columbus, OH 43210
Thomas J. Rosol
The Ohio State University, Department of Veterinary Biosciences, Columbus, OH 43210
John Foley
Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202

ABSTRACT

Parathyroid hormone-related protein (PTHrP) came to the attention of the scientific community in the mid-1980s because of its association with the paraneoplastic syndrome of humoral hypercalcemia of malignancy. Recently, a crucial role for the peptide has been identified in the metastatic growth of cancer cells in bone. Efforts to understand the peptide's role in these pathological processes have evolved into the study of PTHrP gene expression. Currently, regulation of the third PTHrP promoter is beginning to be understood in the context of activation of certain signaling pathways involved in the growth and progression of specific neoplasms. In addition, factors that modulate the entire PTHrP-transcriptional unit, as well as the stability of the mRNA, are being elucidated at the level of cis-acting sequences.


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