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ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

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DOI: 10.1615/CritRevEukaryotGeneExpr.v15.i2.20
pages 103-114

Rho Proteins in Cell Migration and Metastasis

Brian Titus
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA
Martin A. Schwartz
Department of Microbiology, Department of Biomedical Engineering, University of Virginia, Charlottesville, VA
Dan Theodorescu
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA; Department of Pharmacology, University of Colorado, Denver, Colorado; Department of Surgery (Urology), University of Colorado, Denver, Colorado; University of Colorado Comprehensive Cancer Center, Denver, Colorado

ABSTRACT

The ability of tumors to invade, colonize, and destroy distant organs was first recognized by Jean-Claude Recamier in 1829. He termed this phenomenon metastasis.1,2 Since it was first described, metastasis has been shown to be a complex multistep process.3 One important step is cell migration—a critical component of both cancer-cell invasion at the primary site (allowing cells to gain access to the vasculature) and for cells to penetrate the host tissue at distant sites.4 The aim of this review is to examine the fundamental role of migration in cancer progression and to discuss the role of the Rho family of small G proteins and their effectors in this process.


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