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ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Regulation and Repair of Double-Strand DNA Breaks

卷 6, 册 4, 1996, pp. 345-375
DOI: 10.1615/CritRevEukarGeneExpr.v6.i4.20
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摘要

Double-strand break (DSB) repair in mammalian cells involves the DNA-dependent protein kinase (DNA-PK). DNA-PK is composed of three subunits, a catalytic kinase subunit (DNA-PKcs) mutated in the mouse scid complementation group and the Ku heterodimer. Ku-deficient and DNA-PKcs-deficient cell lines and an animal model have illuminated important features of the DSB repair pathway. Additional factors relevant to several essential functions of DNA replication may point to some overlap between DNA synthesis and DNA repair in eukaryotes. The DNA-PK complex may have broader functions based on its possible involvement in transcriptional regulation and cell cycle checkpoints.

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