图书馆订阅: Guest
真核基因表达评论综述™

每年出版 6 

ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Mesenchymal Stem Cells in the Aging and Osteoporotic Population

卷 21, 册 4, 2011, pp. 363-377
DOI: 10.1615/CritRevEukarGeneExpr.v21.i4.60
Get accessGet access

摘要

Because of their ability to self-renew and differentiate, mesenchymal stem cells (MSCs) are the in vivo source for replacing lost cells in high-turnover tissues during the life of an organism. MSCs have osteogenic potential and can be eligible for the repair and maintenance of the skeleton, thus they are very attractive for tissue engineering and regenerative medicine approaches. However, many changes in their behavior, caused by aging and bone disease, have been reported in the literature. These changes, which affect MSC self-renewal ability and differentiation potentiality, are related to cell proliferation, differentiation, cell cycle phases (depending on gene modification), and cytokine and growth factor production. This review summarizes the literature related to intrinsic and extrinsic characteristics of human bone marrow or adipose tissue MSCs during aging and osteoporosis. Although some studies reveal contrasting results, the results of this review suggest that the cellular modifications due to aging and osteoporosis should be carefully considered in relation to the use of MSCs for therapeutic application.

对本文的引用
  1. Li Guan-Wu, Chang Shi-Xin, Fan Jing-Zheng, Tian Ya-Nan, Xu Zheng, He Yan-Ming, Marrow adiposity recovery after early zoledronic acid treatment of glucocorticoid-induced bone loss in rabbits assessed by magnetic resonance spectroscopy, Bone, 52, 2, 2013. Crossref

  2. Allahverdiyev Adil M., Baydar Serap Yesilkir, Bagirova Melahat, Findikli Necati, Microcapillary Culture Method: A Novel Tool for In Vitro Expansion of Stem Cells from Scarce Sources, Archives of Medical Research, 43, 6, 2012. Crossref

  3. Veronesi Francesca, Giavaresi Gianluca, Tschon Matilde, Borsari Veronica, Nicoli Aldini Nicolò, Fini Milena, Clinical Use of Bone Marrow, Bone Marrow Concentrate, and Expanded Bone Marrow Mesenchymal Stem Cells in Cartilage Disease, Stem Cells and Development, 22, 2, 2013. Crossref

  4. Holzapfel Boris Michael, Reichert Johannes Christian, Schantz Jan-Thorsten, Gbureck Uwe, Rackwitz Lars, Nöth Ulrich, Jakob Franz, Rudert Maximilian, Groll Jürgen, Hutmacher Dietmar Werner, How smart do biomaterials need to be? A translational science and clinical point of view, Advanced Drug Delivery Reviews, 65, 4, 2013. Crossref

  5. Guang Liang G., Boskey Adele L., Zhu Wei, Age-related CXC chemokine receptor-4-deficiency impairs osteogenic differentiation potency of mouse bone marrow mesenchymal stromal stem cells, The International Journal of Biochemistry & Cell Biology, 45, 8, 2013. Crossref

  6. Yoon Hyang-Jin, Seo Cho-Rong, Kim MiAe, Kim Young-Jun, Song No-Joon, Jang Woo-Seok, Kim Byung-Joon, Lee JaeHwan, Hong Joung-Woo, Nho Chu Won, Park Kye Won, Dichloromethane extracts of Sophora japonica L. stimulate osteoblast differentiation in mesenchymal stem cells, Nutrition Research, 33, 12, 2013. Crossref

  7. Siclari Valerie A., Zhu Ji, Akiyama Kentaro, Liu Fei, Zhang Xianrong, Chandra Abhishek, Nah Hyun-Duck, Shi Songtao, Qin Ling, Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow, Bone, 53, 2, 2013. Crossref

  8. Jakob Franz, Ebert Regina, Ignatius Anita, Matsushita Takashi, Watanabe Yoshinobu, Groll Juergen, Walles Heike, Bone tissue engineering in osteoporosis, Maturitas, 75, 2, 2013. Crossref

  9. Park Dongsu, Hoggatt Jonathan, Ferraro Francesca, Scadden David T., The Skeletal Stem Cell, in Osteoporosis, 2013. Crossref

  10. Veronesi Francesca, Pagani Stefania, Della Bella Elena, Giavaresi Gianluca, Fini Milena, Estrogen deficiency does not decrease the in vitro osteogenic potential of rat adipose-derived mesenchymal stem cells, AGE, 36, 3, 2014. Crossref

  11. Ming Leiguo, Jin Fang, Huang Ping, Luo Hailang, Liu Wenjia, Zhang Leilei, Yuan Wei, Zhang Yongjie, Jin Yan, Licochalcone A up-regulates of FasL in mesenchymal stem cells to strengthen bone formation and increase bone mass, Scientific Reports, 4, 1, 2015. Crossref

  12. You Li, Chen Lin, Pan Ling, Gu Wen-sha, Chen Jin-Yu, Zinc finger protein 467 regulates Wnt signaling by modulating the expression of sclerostin in adipose derived stem cells, Biochemical and Biophysical Research Communications, 456, 2, 2015. Crossref

  13. Qiu Y., Yao J., Wu X., Zhou B., Shao H., Hua T., Xiong Z., Tang G., Longitudinal assessment of oxytocin efficacy on bone and bone marrow fat masses in a rabbit osteoporosis model through 3.0-T magnetic resonance spectroscopy and micro-CT, Osteoporosis International, 26, 3, 2015. Crossref

  14. Ferretti Concetta, Lucarini Guendalina, Andreoni Chiara, Salvolini Eleonora, Bianchi Novella, Vozzi Giovanni, Gigante Antonio, Mattioli-Belmonte Monica, Human Periosteal Derived Stem Cell Potential: The Impact of age, Stem Cell Reviews and Reports, 11, 3, 2015. Crossref

  15. Lynch Kevin, Pei Ming, Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies, Organogenesis, 10, 3, 2014. Crossref

  16. Iohara Koichiro, Murakami Masashi, Nakata Kazuhiko, Nakashima Misako, Age-dependent decline in dental pulp regeneration after pulpectomy in dogs, Experimental Gerontology, 52, 2014. Crossref

  17. Mattei Giorgio, Ferretti Concetta, Tirella Annalisa, Ahluwalia Arti, Mattioli-Belmonte Monica, Decoupling the role of stiffness from other hydroxyapatite signalling cues in periosteal derived stem cell differentiation, Scientific Reports, 5, 1, 2015. Crossref

  18. Cipriani Paola, Ruscitti Piero, Di Benedetto Paola, Carubbi Francesco, Liakouli Vasiliki, Berardicurti Onorina, Ciccia Francesco, Triolo Giovanni, Giacomelli Roberto, Mesenchymal stromal cells and rheumatic diseases: new tools from pathogenesis to regenerative therapies, Cytotherapy, 17, 7, 2015. Crossref

  19. Jang Woo-Seok, Seo Cho-Rong, Jang Hwan Hee, Song No-Joon, Kim Jong-Keun, Ahn Jee-Yin, Han Jaejoon, Seo Woo Duck, Lee Young Min, Park Kye Won, Black rice (Oryza sativa L.) extracts induce osteoblast differentiation and protect against bone loss in ovariectomized rats, Food & Function, 6, 1, 2015. Crossref

  20. Song No-Joon, Kwon So-Mi, Kim Suji, Yoon Hyang-Jin, Seo Cho-Rong, Jang Byunghyun, Chang Seo-Hyuk, Ku Jin-Mo, Lee Jeong-Soo, Park Ki-Moon, Hong Joung-Woo, Kim Geun Hyung, Park Kye Won, Sulfuretin induces osteoblast differentiation through activation of TGF-β signaling, Molecular and Cellular Biochemistry, 410, 1-2, 2015. Crossref

  21. Veronesi Francesca, Salamanna Francesca, Tschon Matilde, Maglio Melania, Nicoli Aldini Nicolo, Fini Milena, Mesenchymal stem cells for tendon healing: what is on the horizon?, Journal of Tissue Engineering and Regenerative Medicine, 11, 11, 2017. Crossref

  22. Wicks George G., Hill William D., Weinberger Paul M., Tiny Bubbles; Composite Cocktails for Medical Applications, International Journal of Applied Glass Science, 7, 2, 2016. Crossref

  23. Wang Xing, Zou Xuan, Zhao Jing, Wu Xia, E Lingling, Feng Lin, Wang Dongsheng, Zhang Guilan, Xing Helin, Liu Hongchen, Site-Specific Characteristics of Bone Marrow Mesenchymal Stromal Cells Modify the Effect of Aging on the Skeleton, Rejuvenation Research, 19, 5, 2016. Crossref

  24. Veronesi Francesca, Borsari Veronica, Sartori Maria, Orciani Monia, Mattioli-Belmonte Monica, Fini Milena, The use of cell conditioned medium for musculoskeletal tissue regeneration, Journal of Cellular Physiology, 233, 6, 2018. Crossref

  25. Carbone Laura D., Bůžková Petra, Fink Howard A., Robbins John A., Bethel Monique, Hamrick Mark W., Hill William D., Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study, Calcified Tissue International, 100, 6, 2017. Crossref

  26. Deepak Vishwa, Kruger Marlena C., Joubert Annie, Coetzee Magdalena, Piperine alleviates osteoclast formation through the p38/c-Fos/NFATc1 signaling axis, BioFactors, 41, 6, 2015. Crossref

  27. Jacobs Frans Alexander, van de Vyver Mari, Ferris William Frank, Isolation and Characterization of Different Mesenchymal Stem Cell Populations from Rat Femur, in Pre-Clinical Models, 1916, 2019. Crossref

  28. Veronesi Francesca, Desando Giovanna, Fini Milena, Parrilli Annapaola, Lolli Roberta, Maglio Melania, Martini Lucia, Giavaresi Gianluca, Bartolotti Isabella, Grigolo Brunella, Sartori Maria, Bone marrow concentrate and expanded mesenchymal stromal cell surnatants as cell-free approaches for the treatment of osteochondral defects in a preclinical animal model, International Orthopaedics, 43, 1, 2019. Crossref

  29. Corrigan Michele A., Johnson Gillian P., Stavenschi Elena, Riffault Mathieu, Labour Marie-Noelle, Hoey David A., TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium, Scientific Reports, 8, 1, 2018. Crossref

  30. Mao Lei, Wang Meiling, Li Yuanyuan, Liu Yaxuan, Wang Jingfeng, Xue Changhu, Docosahexaenoic acid‐containing phosphatidylcholine induced osteoblastic differentiation by modulating key transcription factors, Journal of Food Biochemistry, 42, 6, 2018. Crossref

  31. Wu Zhixin, Pan Zhengqi, Wen Yinxian, Xiao Hao, Shangguan Yangfan, Wang Hui, Chen Liaobin, Egr1/p300/ACE signal mediates postnatal osteopenia in female rat offspring induced by prenatal ethanol exposure, Food and Chemical Toxicology, 136, 2020. Crossref

  32. Lepperdinger Günter, Reitinger Stephan, Aging of Human Mesenchymal Stem Cells, in Stem Cell Aging: Mechanisms, Consequences, Rejuvenation, 2015. Crossref

  33. Zhu Yuan, Zhang Xiao, Gu Ranli, Liu Xuenan, Wang Siyi, Xia Dandan, Li Zheng, Lian Xiaomin, Zhang Ping, Liu Yunsong, Zhou Yongsheng, LAMA2 regulates the fate commitment of mesenchymal stem cells via hedgehog signaling, Stem Cell Research & Therapy, 11, 1, 2020. Crossref

  34. Park Dongsu, Ortinau Laura, Hoggatt Jonathan, Scadden David T., The skeletal stem cell, in Marcus and Feldman's Osteoporosis, 2021. Crossref

  35. Zhu Mo , Hao Guangyu , Xing Jianming , Hu Su , Geng Dechun , Zhang Wen , Wang Qianqian , Hu Chunhong , Wang Ximing , Bone marrow adipose amount influences vertebral bone strength, Experimental and Therapeutic Medicine, 2018. Crossref

  36. Zhao Guifang, Liu Feilin, Lan Shaowei, Li Pengdong, Wang Li, Kou Junna, Qi Xiaojuan, Fan Ruirui, Hao Deshun, Wu Chunling, Bai Tingting, Li Yulin, Liu Jin Yu, Large-scale expansion of Wharton’s jelly-derived mesenchymal stem cells on gelatin microbeads, with retention of self-renewal and multipotency characteristics and the capacity for enhancing skin wound healing, Stem Cell Research & Therapy, 6, 1, 2015. Crossref

  37. Corrigan Michele A., Coyle Siobhan, Eichholz Kian F., Riffault Mathieu, Lenehan Brian, Hoey David A., Aged Osteoporotic Bone Marrow Stromal Cells Demonstrate Defective Recruitment, Mechanosensitivity, and Matrix Deposition, Cells Tissues Organs, 207, 2, 2019. Crossref

  38. Tsuno Hiroaki, Yoshida Toshiko, Nogami Makiko, Koike Chika, Okabe Motonori, Noto Zenko, Arai Naoya, Noguchi Makoto, Nikaido Toshio, Application of human amniotic mesenchymal cells as an allogeneic transplantation cell source in bone regenerative therapy, Materials Science and Engineering: C, 32, 8, 2012. Crossref

  39. Tschon Matilde, Boanini Elisa, Sartori Maria, Salamanna Francesca, Panzavolta Silvia, Bigi Adriana, Fini Milena, Antiosteoporotic Nanohydroxyapatite Zoledronate Scaffold Seeded with Bone Marrow Mesenchymal Stromal Cells for Bone Regeneration: A 3D In Vitro Model, International Journal of Molecular Sciences, 23, 11, 2022. Crossref

  40. Zhang Xianning, Liu Lulu, Dou Cuiyun, Cheng Panpan, Liu Lei, Liu Haihui, Ren Saisai, Wang Cuiling, Jia Shu, Chen Lulu, Zhang Hao, Chen Mingtai, PPAR Gamma-Regulated MicroRNA 199a-5p Underlies Bone Marrow Adiposity in Aplastic Anemia, Molecular Therapy - Nucleic Acids, 17, 2019. Crossref

  41. Yoon Dong Suk, Lee Kyoung-Mi, Choi Yoorim, Ko Eun Ae, Lee Na-Hyun, Cho Sehee, Park Kwang Hwan, Lee Jung-Hwan, Kim Hae-Won, Lee Jin Woo, TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis, Cell Death & Differentiation, 29, 7, 2022. Crossref

将发表的论文

PRMT6 promotes the immune evasion of gastric cancer via upregulating ANXA1 Liang Xu, Fenger Zhang, Binqi Yu, Shengnan Jia, Sunfu Fan PURPL promotes M2 macrophage polarization in lung cancer via regulating RBM4/xCT signaling Jipeng Guo, Chongwen Gong, Hao Wang SIAH1 promotes the pyroptosis of cardiomyocytes in diabetic cardiomyopathy via regulating IκB-α/NF-κB signaling Jinbin Wu, Yaoming Yan SLC7A2-mediated lysine catabolism inhibits immunosuppression in triple negative breast cancer Yuanyuan Sun, Yaqing Li, Chengying Jiang, Chenying Liu, Yuanming Song SIAH2-mediated degradation of ACSL4 inhibits the anti-tumor activity of CD8+ T cells in hepatocellular carcinoma Fangzheng Shu, Yuhua Shi, Xiangxiang Shan, Wenzhang Zha, Rengen Fan, Wanjiang Xue RBM15-mediated N6-methyl adenosine (m6A) modification of EZH2 drives the epithelial-mesenchymal transition of cervical cancer Ruixue Wang, Wenhua Tan Evidence-Based Storytelling and A Strategic Roadmap to Promote Cancer Prevention Via Adolescent HPV Vaccination in Northern New England Matthew Dugan, Gary Stein, Jan Carney, Sheila Clifford-Bova KDM4A-AS1 promotes cell proliferation, migration and invasion via the miR-4306/STX6 axis in hepatocellular carcinoma Wei Cao, Yuhan Ren, Ying Liu, Guoshu Cao, Zhen Chen, Fan Wang HDAC1-mediated downregulation of NEU1 exacerbates the aggressiveness of cervical cancer Nanzi Xie, Sisi Mei, Changlan Dai, Wei Chen Effect of miR-26b-5p on progression of acute myeloid leukemia by regulating USP48-mediated Wnt/β-catenin pathway Yu Xie, Lin Tan, Kun Wu, Deyun Li, Chengping Li
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain