图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
真核基因表达评论综述™
影响因子: 1.841 5年影响因子: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukarGeneExpr.v21.i4.20
pages 313-322

mTOR Regulates T-Cell Differentiation and Activation in Immunity and Autoimmunity

Yujing Bi
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing China
Guangwei Liu
Institute of Zoology, Chinese Academy of Science
Ruifu Yang
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing China

ABSTRACT

mTOR is an evolutionarily conserved PI3-kinase family member that plays a central role in integrating environmental cues in the form of amino acids, energy, and growth factors. Recently, the kinase mTOR has emerged as an important regulator of the differentiation and function of helper T cells in immune responses and autoimmune diseases. In this review, we summarize the regulatory effects and mechanisms of mTOR complex in the differentiation of CD4+ T and CD8+ T cells, and T-cell homeostasis modulation. This should contribute to understanding the central role for mTOR in regulating immune responses and autoimmune diseases.


Articles with similar content:

Role of IL-21 and IL-21 Receptor on B Cells in HIV Infection
Critical Reviews™ in Immunology, Vol.32, 2012, issue 2
Suresh Pallikkuth, Savita Pahwa, Anita Parmigiani
Regulation of Th17 Maturation by Interleukin 4
Critical Reviews™ in Immunology, Vol.33, 2013, issue 5
Laura A. Cooney , David A. Fox
IL-7 and IL-15: Biology and Roles in T-Cell Immunity in Health and Disease
Critical Reviews™ in Immunology, Vol.28, 2008, issue 4
Kyung-A Hwang, Insoo Kang, Sung-Hwan Park, Hang-Rae Kim
Regulation of Regulatory T Cells: Role of Dendritic Cells and Toll-Like Receptors
Critical Reviews™ in Immunology, Vol.26, 2006, issue 4
Dieter Kabelitz, Daniela Wesch, Hans-Heinrich Oberg
CD40 and Dendritic Cell Function
Critical Reviews™ in Immunology, Vol.23, 2003, issue 1-2
Ranjeny Thomas, Brendan O'Sullivan