图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
真核基因表达评论综述™
影响因子: 2.156 5年影响因子: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukaryotGeneExpr.2019025941
pages 161-170

Does Circular RNA Exert Significant Effects in Ovarian Cancer?

Ying Feng
Department of Obstetrics and Gynecology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China
Qiushi Wang
Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
Can Shi
Department of Obstetrics and Gynecology, Huai'an First People's Hospital, Nanjing Medical University Huai'an 223300, Jiangsu, China
Chongdong Liu
Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
Zhenyu Zhang
Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

ABSTRACT

Circular RNA, also called circRNA, is a type of widespread RNA that is mainly derived from the spliceosome, from which DNA is transcribed into messenger RNA (mRNA). CircRNAs are characterized by the formation of a covalently closed continuous loop, and they play a variety of gene regulatory roles. CircRNAs were initially thought to represent splicing errors, but an increasing amount of evidence indicates that they may play significant roles in a variety of human diseases, including cancers, cardiovascular disease, neurological disorders, and pre-eclampsia. Studies have suggested that circRNAs regulate miRNA activity that arises from miRNA-mediated sponge effects. It has been shown that CDR1as acts as a sponge for miR-7 and that a testis-specific circRNA within the sex-determining region of Y (SRY) acts as a sponge for miR-138. Because miR-7 and miR-138 modulate several oncogenes and tumor suppressor genes, the interactions between ciRS-7 and miR-7 and between SRY and miR-138 may play important roles in cancer-related pathways. Hence, currently available data suggest that circRNAs may exert significant effects on diagnoses, prognoses, and therapies in ovarian cancer.


Articles with similar content:

Pathogenesis of Psoriatic Arthritis
Critical Reviews™ in Immunology, Vol.39, 2019, issue 5
Maria Sole Chimenti, Francesco Caso, Luca Navarini, Luisa Costa, Leonardo Punzi
Pathogenesis of HIV-1 Associated Neurodegeneration
Critical Reviews™ in Neurobiology, Vol.10, 1996, issue 1
Lennart Mucke, Eliezer Masliah, Nianfeng Ge
Genes Associated with Human Cancers: Their Expressions, Features, Functions, and Significance
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 3
Ravi Maddaly, Bellona Sahu, Divya K. Mohan
Gaucher Disease and Malignancy: A Model for Cancer Pathogenesis in an Inborn Error of Metabolism
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 3
Stephan vom Dahl, Pramod K. Mistry, Barry E. Rosenbloom, Tamar Taddei
Breakpoint Clusters: Reason or Consequence?
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 1&2
Andrey A. Bystritskiy, Sergey V. Razin