图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
真核基因表达评论综述™
影响因子: 1.841 5年影响因子: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukarGeneExpr.v17.i3.40
pages 215-240

Pathophysiology and Genetics of Metabolic Bone Disorders Characterized by Increased Bone Turnover

Greet Beyens
Department of Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium
Wim Van Hul
Department of Medical Genetics, University of Antwerp (UA) and Department of Medical Genetics, University Hospital of Antwerp (UZA)

ABSTRACT

Bone is the most important supportive tissue in the human body, and in order to maintain its integrity, it is continuously renewed by a process called "remodeling". Paget's disease of bone (PDB), familial expansile osteolysis (FEO), expansile skeletal hyperphosphatasia (ESH), early-onset Paget's disease of bone (EOPDB), and juvenile Paget's disease (JPD) are all metabolic bone disorders characterized by accelerated bone remodeling. Histological studies have shown that bone-resorbing osteoclasts are the primary disease-causing cells in these disorders. In this review, we provide an overview of the clinical differences between diseases with increased bone turnover. Our main focus is on Paget's disease because this is, by far, the most common form of this type of disease. Molecular genetic studies of these disorders have revealed key players in bone remodeling and have provided further insights in signal transduction in osteoclasts. Moreover, a syndromal form of PDB has been characterized in which PDB is associated with inclusion body myopathy and frontotemporal dementia, pointing toward similar biological pathways in osteoclasts, muscle, and brain cells. However, several additional genes underlying conditions with increased bone turnover remain to be identified.


Articles with similar content:

Complex Interplay Between Aging and Cancer: Role of TGF-β Signaling
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 3-4
Panagiotis Papageorgis
The Molecular and Cellular Biology of Pancreatic Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 3-4
Theodore P. McDade, Frank J. Vittimberga, Jr. , Richard A. Perugini, Mark P. Callery
Signaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 1
Shuying Yang, Wei Chen, Carrie S. Soltanoff, Yi-Ping Li
Epigenetic Transgenerational Actions of Vinclozolin on the Development of Disease and Cancer
Critical Reviews™ in Oncogenesis, Vol.13, 2007, issue 1
Matthew D. Anway, Michael K. Skinner
Thymus-Derived Signals Regulate Early T-Cell Development
Critical Reviews™ in Immunology, Vol.25, 2005, issue 2
Thomas M. Schmitt, Juan Carlos Zuniga-Pflucker