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ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

The Epigenetics of Adult (Somatic) Stem Cells

卷 18, 册 3, 2008, pp. 189-206
DOI: 10.1615/CritRevEukarGeneExpr.v18.i3.10
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摘要

While genetic studies have provided a wealth of information about health and disease, there is a growing awareness that individual characteristics are also determined by factors other than genetic sequences. These "epigenetic" changes broadly encompass the influence of the environment on gene regulation and expression and in a more narrow sense, describe the mechanisms controlling DNA methylation, histone modification and genetic imprinting. In this review, we focus on the epigenetic mechanisms that regulate adult (somatic) stem cell differentiation, beginning with the metabolic pathways and factors regulating chromatin structure and DNA methylation and the molecular biological tools that are currently available to study these processes. The role of these epigenetic mechanisms in manipulating adult stem cells is followed by a discussion of the challenges and opportunities facing this emerging field.

对本文的引用
  1. Taubenschmid Jasmin, Weitzer Georg, , 293, 2012. Crossref

  2. Xie Lin, Zhang Nan, Marsano Anna, Vunjak-Novakovic Gordana, Zhang Yanru, Lopez Mandi J., In Vitro Mesenchymal Trilineage Differentiation and Extracellular Matrix Production by Adipose and Bone Marrow Derived Adult Equine Multipotent Stromal Cells on a Collagen Scaffold, Stem Cell Reviews and Reports, 9, 6, 2013. Crossref

  3. Kar Swayamsiddha, Parbin Sabnam, Deb Moonmoon, Shilpi Arunima, Sengupta Dipta, Rath Sandip Kumar, Rakshit Madhumita, Patra Aditi, Patra Samir Kumar, Epigenetic choreography of stem cells: the DNA demethylation episode of development, Cellular and Molecular Life Sciences, 71, 6, 2014. Crossref

  4. Pachón-Peña G., Yu G., Tucker A., Wu X., Vendrell J., Bunnell B.A., Gimble J.M., Stromal stem cells from adipose tissue and bone marrow of age-matched female donors display distinct immunophenotypic profiles, Journal of Cellular Physiology, 226, 3, 2011. Crossref

  5. Vanhaecke T., Snykers S., Rogiers V., Garthoff B., Castell J. V., Hengstler J. G., EU research activities in alternative testing strategies: current status and future perspectives, Archives of Toxicology, 83, 12, 2009. Crossref

  6. Robb Sofia M.C., Alvarado Alejandro Sánchez, Histone Modifications and Regeneration in the Planarian Schmidtea mediterranea, in Mechanisms of Regeneration, 108, 2014. Crossref

  7. Lopez M. J., Jarazo J., State of the art: Stem cells in equine regenerative medicine, Equine Veterinary Journal, 47, 2, 2015. Crossref

  8. Grayson Warren L., Bunnell Bruce A., Martin Elizabeth, Frazier Trivia, Hung Ben P., Gimble Jeffrey M., Stromal cells and stem cells in clinical bone regeneration, Nature Reviews Endocrinology, 11, 3, 2015. Crossref

  9. Cooney Craig A., Drugs and supplements that may slow aging of the epigenome, Drug Discovery Today: Therapeutic Strategies, 7, 3-4, 2010. Crossref

  10. Xu Yue, Hammerick Kyle E., James Aaron W., Carre Antoine L., Leucht Philipp, Giaccia Amato J., Longaker Michael T., Inhibition of Histone Deacetylase Activity in Reduced Oxygen Environment Enhances the Osteogenesis of Mouse Adipose-Derived Stromal Cells, Tissue Engineering Part A, 15, 12, 2009. Crossref

  11. Duan Wei, Lopez Mandi J., Canine Adult Adipose Tissue-Derived Multipotent Stromal Cell Isolation and Characterization, in Adipose-Derived Stem Cells, 1773, 2018. Crossref

  12. Cooney Craig A., Epigenetic Alterations due to Trichloroethylene, in Trichloroethylene: Toxicity and Health Risks, 2014. Crossref

  13. Cooney Craig A., Dietary Restriction, Dietary Design and the Epigenetics of Aging and Longevity, in Nutrition, Exercise and Epigenetics: Ageing Interventions, 2, 2014. Crossref

  14. Carvalho Pedro P., Gomes Manuela E., Reis Rui L., Gimble Jeffrey M., Adipose Tissue-Derived MSCs: Moving to the Clinic, in Mesenchymal Stromal Cells, 2013. Crossref

  15. Tan Kah Yong, Kim Francis S., Wagers Amy J., Mayack Shane R., Hematopoietic Stem Cells and Somatic Stem Cells, in Hematopoietic Stem Cell Biology, 2010. Crossref

  16. Zhao Qian, Zhang Yong, Epigenome sequencing comes of age in development, differentiation and disease mechanism research, Epigenomics, 3, 2, 2011. Crossref

  17. Cooney Craig A., Gilbert Kathleen M., Toxicology, Epigenetics, and Autoimmunity, in Toxicology and Epigenetics, 2012. Crossref

  18. Hanak K., Neuhaus W., Weinhäusel A., Epigenetics and Its Implications for Tissue Regeneration and Regenerative Medicine with a Focus on DNA-Methylation, in Cell Engineering and Regeneration, 2021. Crossref

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