每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
Response of Osteoblasts to the Stimulus of Fluid Flow
摘要
Bone is an important porous tissue that supports the body, maintains calcium and phosphate homeostasis, protects vital organs, and houses bone marrow. The interaction between hydrostatic pressure and fluid phase, solid phase, cells, and vascular in bone makes bone inevitably bear baseline levels of fluid flow. Fluid flow plays an important role in regulating the proliferation, differentiation, distribution, and apoptosis of osteoblasts in bone. The effect of fluid flow on osteoblasts is dependent on time, velocity, and type. Some response of osteoblasts to fluid flow is closely related to the soluble factors secreted by the osteoblasts themselves or other types of bone cells. When the response is disordered, related bone diseases such as osteoporosis, osteoarthritis, and abnormal osteogenesis probably happen. In this article we review the current progress in the study of the response of osteoblasts to the direct and indirect stimulus of fluid flow and their roles in osteogenesis and related bone diseases.
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Lyons James S., Iyer Shama R., Lovering Richard M., Ward Christopher W., Stains Joseph P., Novel multi-functional fluid flow device for studying cellular mechanotransduction, Journal of Biomechanics, 49, 16, 2016. Crossref
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Huang Wanyue, Wang Peiyan, Shen Tongtong, Hu Chongwei, Han Yanfei, Song Miao, Bian Yu, Li Yanfei, Zhu Yanzhu, Aluminum Trichloride Inhibited Osteoblastic Proliferation and Downregulated the Wnt/β-Catenin Pathway, Biological Trace Element Research, 177, 2, 2017. Crossref
-
Huang Lingwei, Korhonen Rami K., Turunen Mikael J., Finnilä Mikko A.J., Experimental mechanical strain measurement of tissues, PeerJ, 7, 2019. Crossref
-
Alfieri Roberta, Vassalli Massimo, Viti Federica, Flow-induced mechanotransduction in skeletal cells, Biophysical Reviews, 11, 5, 2019. Crossref