每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
MicroRNAs in Gastric Cancer Metastasis
摘要
Gastric cancer (GC) is common worldwide and has a high rate of metastasis. The underlying molecular mechanism of metastasis are not entirely clear. MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression post-transcriptionally and are reported to be involved in multiple steps of tumor metastasis. Clarifying their roles in GC metastasis will improve understanding of this disease. Here, we review the involvement of miRNAs in multiple steps of GC metastasis, including epithelial−mesenchymal transitions, anoikis, angiogenesis, invasion, and migration. The clinical application of miRNAs as prognostic biomarkers in GC is also discussed.
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Kowalik Casey G., Palmer Drew A., Sullivan Travis B., Teebagy Patrick A., Dugan John M., Libertino John A., Burks Eric J., Canes David, Rieger-Christ Kimberly M., Profiling microRNA from nephrectomy and biopsy specimens: predictors of progression and survival in clear cell renal cell carcinoma, BJU International, 120, 3, 2017. Crossref
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Zhu Yaodong, Liu Yanqing, Qian Yayun, Dai Xiaojun, Yang Lin, Chen Jue, Guo Shiyu, Hisamitsu Tadashi, Antimetastatic Effects of Celastrus orbiculatus on Human Gastric Adenocarcinoma by Inhibiting Epithelial–Mesenchymal Transition and NF-κB/Snail Signaling Pathway, Integrative Cancer Therapies, 14, 3, 2015. Crossref
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Debiec K., Wydmanski J., Gastric Cancer Metastasis, in Introduction to Cancer Metastasis, 2017. Crossref
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Tan Bi-bo, Li Yong, Fan Li-qiao, Zhao Qun, Liu Qing-wei, Liu Yü, Wang Dong, Jia Nan, Upregulated Vav2 in gastric cancer tissues promotes tumor invasion and metastasis, Tumor Biology, 39, 5, 2017. Crossref
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Zhu Meng, Zhang Ning, Lu Xinlan, He Shuixiang, Negative Regulation of Kruppel-Like Factor 4 on microRNA-106a at Upstream Transcriptional Level and the Role in Gastric Cancer Metastasis, Digestive Diseases and Sciences, 63, 10, 2018. Crossref
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Cheng Zhenguo, Liu Funan, Zhang Hongyan, Li Xiaodong, Li Yanshu, Li Jiabin, Liu Furong, Cao Yu, Cao Liu, Li Feng, miR-135a inhibits tumor metastasis and angiogenesis by targeting FAK pathway, Oncotarget, 8, 19, 2017. Crossref
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Li Juan, Meng Hui, Bai Yun, Wang Kai, Regulation of lncRNA and Its Role in Cancer Metastasis, Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 23, 5, 2016. Crossref
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Xin Rui, Tang Xiao-Mei, Jiang Ying-Jie, Yu Fei, Li Sha, Jia Cheng-You, Wang Gao-Ren, Fu Da, Liu Ji-Bin, Ma Yu-Shui, Zheng Mingjun, Construction of a Novel MYC-Associated ceRNA Regulatory Network to Identify Prognostic Biomarkers in Colon Adenocarcinoma, Journal of Oncology, 2022, 2022. Crossref
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Liu Funan, Cheng Zhenguo, Li Xiaodong, Li Yanshu, Zhang Hongyan, Li Jiabin, Liu Furong, Xu Huimian, Li Feng, A Novel Pak1/ATF2/miR-132 Signaling Axis Is Involved in the Hematogenous Metastasis of Gastric Cancer Cells, Molecular Therapy - Nucleic Acids, 8, 2017. Crossref