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ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

The Role of the Nuclear Matrix in Cancer Chemotherapy

卷 9, 册 3-4, 1999, pp. 337-343
DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.180
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摘要

The nuclear matrix is the site of many nuclear functions including transcription, replication, formation of chromatin loops, and control of DNA supercoiling. It contains various structural and functional components that represent targets for antineoplastic agents. Antimetabolites and topoisomerase II inhibitors interact specifically with matrix-associated enzymes, DNA primase, and DNA topoisomerase II, respectively. Alkylating agents and ionizing radiation interact with nuclear matrix proteins and matrix-associated DNA. Many nuclear functions, including multidrug resistance, and others which lead to cell death, have been shown to be compromised when these anticancer agents interact with the nuclear matrix.

对本文的引用
  1. Spencer Virginia A., Davie James R., Signal transduction pathways and chromatin structure in cancer cells, Journal of Cellular Biochemistry, 79, S35, 2000. Crossref

  2. Hales B.F., Robaire B., The Male Germ Cell as a Target for Toxicants, in Comprehensive Toxicology, 2018. Crossref

  3. Codrington Alexis M., Hales Barbara F., Robaire Bernard, Spermiogenic Germ Cell Phase-Specific DNA Damage Following Cyclophosphamide Exposure, Journal of Andrology, 25, 3, 2004. Crossref

  4. Hales B.F., Robaire B., The Male Germ Cell as a Target for Toxicants, in Comprehensive Toxicology, 2010. Crossref

  5. Codrington Alexis M., Hales Barbara F., Robaire Bernard, Chronic Cyclophosphamide Exposure Alters the Profile of Rat Sperm Nuclear Matrix Proteins1, Biology of Reproduction, 77, 2, 2007. Crossref

  6. Chen Hai-Bin, Human papillomavirus 16 E6 is associated with the nuclear matrix of esophageal carcinoma cells, World Journal of Gastroenterology, 7, 6, 2001. Crossref

  7. Leman Eddy S., Getzenberg Robert H., Nuclear matrix proteins as biomarkers in prostate cancer, Journal of Cellular Biochemistry, 86, 2, 2002. Crossref

  8. Lee Wei‐Hwa, Chen Li‐Ching, Lee Chia‐Jung, Huang Chi‐Cheng, Ho Yuan‐Soon, Yang Po‐Sheng, Ho Chi‐Tang, Chang Hang‐Lung, Lin I‐Hsuan, Chang Hui‐Wen, Liu Yun‐Ru, Wu Chih‐Hsiung, Tu Shih‐Hsin, DNA primase polypeptide 1 (PRIM1) involves in estrogen‐induced breast cancer formation through activation of the G2/M cell cycle checkpoint, International Journal of Cancer, 144, 3, 2019. Crossref

  9. Majumder Parijat, Pradhan Suman K., Devi Pukhrambam Grihanjali, Pal Sudipta, Dasgupta Dipak, Chromatin as a Target for the DNA-Binding Anticancer Drugs, in Chromatin and Disease, 41, 2007. Crossref

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