图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
真核基因表达评论综述™
影响因子: 1.841 5年影响因子: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.20
pages 175-182

Evolution of Transcriptional Control from Prokaryotic Beginnings to Eukaryotic Complexities

Lili Huang
Dana Farber Cancer Institute, 44 Binney St., Boston, MA 02115
Rong J. Guan
Dana Farber Cancer Institute, 44 Binney St., Boston, MA 02115
Arthur B. Pardee
Dana Farber Cancer Institute, 44 Binney St., Boston, MA 02115

ABSTRACT

Mechanisms for regulating gene transcription became increasingly complex as organisms evolved. In prokaryotes the relatively simple mechanism of repression is based on a few proteins that bind to specific DNA sequences in a ligand-dependent fashion. In eukaryotes large complexes that include ligand binding proteins regulate transcription. Lower eukaryotes developed an additional level of control based on protein complexes that include modifying enzymes. The DNA/histone complex, in combination with gene-specific transcriptional factors, is the basis of gene regulation in eukaryotes. Higher eukaryotes took regulation a level further by methylating CpGs in promoter sequences of DNA, thereby allowing binding of histone deacetylases and inhibiting transcription. Finally, long-lasting "superrepression" provides another mechanism for coordinate transcriptional regulation of large blocks of genes.


Articles with similar content:

Cell-Context Dependent TCF/LEF Expression and Function: Alternative Tales of Repression, De-Repression and Activation Potentials
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 3
Catherine D. Mao, Stephen W. Byers
Mechanisms Controlling Embryonic Stem Cell Self-Renewal and Differentiation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.16, 2006, issue 3
Huai Li, Ming Zhan, Henry Yang, Yu Sun, Mahendra S. Rao
Coactivation and Corepression in Transcriptional Regulation by Steroid/Nuclear Hormone Receptors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 2
J. Don Chen, Hui Li
Histone Deacetylase Co-Repressor Complex Control of Runx2 and Bone Formation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 3
Aswathy K. Nair, Eric D. Jensen, Jennifer J. Westendorf
Cell Cycle and Cancer: Critical Events at the G1 Restriction Point
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 1-2
Michele Pagano, Massimo Loda, Giannino DelSal