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The Critical Role of the miR-21−MEG2 Axis in Colorectal Cancer

卷 30, 册 6, 2020, pp. 509-518
DOI: 10.1615/CritRevEukaryotGeneExpr.2020036484
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Zengtao Bao
Department of Gastrointestinal Surgery, The First People's Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, P.R. China
Shanting Gao
Department of Gastrointestinal Surgery, The First People's Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, P.R. China
Baoming Zhang
Department of Gastrointestinal Surgery, The First People's Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, P.R. China
Wenchao Shi
Department of Gastrointestinal Surgery, The First People's Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, P.R. China
Aimin Li
Department of Neurosurgery, The First People's Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, P.R. China
Qingshui Tian
Department of Gastrointestinal Surgery, The First People's Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, P.R. China

摘要

Protein tyrosine phosphatase MEG2 (MEG2/PTPN9), a classic tyrosine-specific protein tyrosine phosphatase (PTP), is involved in the progression of liver, breast, and gastric cancers. However, the function and regulation of MEG2 in colorectal cancer (CRC) still remain unclear. In this study, we investigated the expression of MEG2 in CRC and found that MEG2 was downregulated in human CRC tissues compared to normal corresponding tissues. Moreover, in vivo and in vitro assays revealed that MEG2 plays a vital role in CRC cell proliferation, invasion, and apoptosis. In addition, mechanism analysis validated miR-21 as a direct regulator of MEG2, and miR-21 plays a critical role in promoting proliferation, invasion, and suppression of apoptosis in CRC by targeting MEG2. Taken together, this study demonstrates the significant role for miR-21 in regulating MEG2 in CRC and may represent a potential target for CRC therapy.

键词: miRNA, proliferation, invasion, apoptosis
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对本文的引用

  1. Lai Chi-Yu, Yeh Kun-Yun, Liu Bi-Feng, Chang Tzu-Ming, Chang Chuan-Hsun, Liao Yung-Feng, Liu Yi-Wen, Her Guor Mour, MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish, Cancers, 13, 21, 2021. Crossref

  2. Tang Xiaolong, Qi Chumei, Zhou Honghong, Liu Yongshuo, Critical roles of PTPN family members regulated by non-coding RNAs in tumorigenesis and immunotherapy, Frontiers in Oncology, 12, 2022. Crossref

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