图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v1.i3.40
pages 227-234

Production of Immunoregulatory Cytokines at Autoimmune Damage of Mammalian Ovaries

Roman I. Yanchii
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tetyana Yu. Voznesenska
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Olena A. Shepel
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tetyana M. Bryzgina
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Vera S. Sukhina
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
L. M. Lazarenko
Kyiv Taras Shevchenko National University, Kyiv, Ukraine
Z. M. Olenivska
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
Mykola Ya. Spivak
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
R. M. Serbenjuk
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
O. M. Serdyuk
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv

ABSTRACT

Several ovarian disorders in women are associated with autoimmune factors. In this study it was investigated a level of cytokines − TNF-α and IFNs in ovarian homogenate and blood serum at ovarian autoimmune damage of mammals. Experimental immune ovarian failure was induced in CBA mice by either immunization with allogenic ovarian extracts or administration of xenogenic anti-ovarian antibodies. Both models were accompanied with abnormalities in production immunoregulatory cytokines. These data confirm importance of definition of proinflammatory cytokine level for disclosing immune mechanisms which lay in a pathogenesis autoimmune ovarian diseases of female reproductive organs.


Articles with similar content:

Recognition of Melanoma-Derived Antigens by CTL: Possible Mechanisms Involved in Down-Regulating Anti-Tumor T-Cell Reactivity
Critical Reviews™ in Immunology, Vol.18, 1998, issue 1-2
Flavio Arienti, Alessandro Borsatti, Paola Squarcina, Chiara Castelli, Filiberto Belli, Ettore Appella, Francesca Rini, Douglas J. Loftus, Francesco M. Marincola, Giorgio Parmiani, Licia Rivoltini, Carsten Geisler
Circulating Osteogenic Precursor Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 2
Robert Pignolo, Eileen M. Shore
Induction of Dendritic Cells (DC) by Flt3 Ligand (FL) Promotes the Generation of Tumor-Specific Immune Responses In Vivo
Critical Reviews™ in Immunology, Vol.18, 1998, issue 1-2
David H. Lynch
Role of Innate Immunity in Transplantation Tolerance
Critical Reviews™ in Immunology, Vol.28, 2008, issue 5
Dale L. Greiner, Aldo A. Rossini, David M. Miller
Macrophages Stimulated by Polysaccharide Purified from Agaricus brasiliensis S.Wasser et al. (Agaricomycetideae) Enhance mRNA Expression of Th1 Cytokine Including IL-12 and 18
International Journal of Medicinal Mushrooms, Vol.5, 2003, issue 4
Nobuhide Fujitake, Sachiko Kawakami, Masashi Mizuno