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国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v1.i3.30
pages 219-226

An Increased Ca2+ Sensitivity of Mitochondrial Permeability Transition Pore in Rat Hearts with Nigrostriatal Dopamine Chronic Deficiency

Sergiy O. Talanov
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Snezhana V. Timoshchuk
Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kyiv
Olena V. Rudyk
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Vadim F. Sagach
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

ABSTRACT

We studied the sensitivity of mitochondrial permeability transition pore (MPTP) opening in response to natural inductor − Ca2+ ions in the rat heart mitochondria which chronic deficiency of nigostriatal dopamine caused by an injection of selective neurotoxin 6-xydroxidofamine in an ascending lateral bundle of the forebrain. MPTP-opening was determined spectrophotometrically (λ = 520 nm) by a decrease in an optical density resulting from mitochondria swelling. It has been shown that the rat heart mitochondria with chronic deficiency of nigrostriatal dopamine are more sensitive to Ca2+ in its physiological concentrations (10−7 M) and overload (10−6 − 10−4 M) in comparison to control animals. Thus, obtained results lead to a conclusion that an increased sensitivity of the mitochondrial permeability transition pore to calcium and mitochondrial membrane permeability may be one of the causes previously reported of disturbance in contractile function of the rat heart with chronic deficiency in nigrostriatal dopamine.


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