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国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v1.i3.20
pages 211-218

Cardioprotective Effects of Flocalin in In Vivo Experiments: Influence of the Hemodynamic and on the Damage of Myocardium under Ischemia-Reperfusion

Ruslan B. Strutynskyi
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Oleksander P. Neshcheret
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Lesya V. Tumanovska
Department of General and Molecular Pathophysiology, Bogomoletz institute of Physiology, Kyiv, Ukraine
Roman A. Rovenets
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Oleksiy O. Moibenko
International Center for Astronomical and Medico-Biological Research, National academy of Sciences of Ukraine, Department of Experimental Cardiology, Department of General and Molecular Pathophysiology, Bogomoletz institute of Physiology, Kyiv, Ukraine

ABSTRACT

In experiments on anesthetized dogs with experimental ischemia (90 min) and reperfusion (180 min) we show the cardioprotective effect of preischemic activation of ATP- sensitive potassium channels (KATP) using intravenous injection of fluorine-containing opener of these channels − flocain in concentration of 0.1 mg/kg, which practically did not change hemodynamic measures under normoxia. Thus, our investigations of flocalin impact on changes in hemodynamic during myocardium ischemia-reperfusion syndrome have shown some peculiarities of ischemia-reperfusion syndrome development under KATP-channels stimulation. From our point of view the positive impacts of flocalin which can support its cardioprotective effects can be arterial pressure lowering, which eases tension on the injured heart and promotes cardiac output retention during the first hours of ischemia. Flocalin-mediated prevention of increase of coronal vascular resistance and retention of myocardial contractility measurements during reperfusion period are of a great importance. All above mentioned flocalin properties promote the reduction of the myocardial infarction area after ischemia-reperfusion by 37% as compared to control.


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