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国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v1.i3.10
pages 201-210

Effects of RNA on Blood Circulation and Its Adrenergic and Cholinergic Regulation

Oleksander P. Neshcheret
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Zenovii Yu. Tkachuk
Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine, Kyiv
Oleksiy O. Moibenko
International Center for Astronomical and Medico-Biological Research, National academy of Sciences of Ukraine, Department of Experimental Cardiology, Department of General and Molecular Pathophysiology, Bogomoletz institute of Physiology, Kyiv, Ukraine

ABSTRACT

Experimental investigations of the impacts of small RNA agent Nucleks on heart function, coronary and systemic circulation as well as on adrenergic and cholinergic mechanisms of cardiohaemodynamics regulation were performed on anaesthetized dogs. Bolus injection (0.1 − 100.0 mg) or prolonged infusion (2.5 mg/min) of Nucleks into perfusion coronary artery blood stream induced coronary dilatation. Under the intracoronary infusion of Nucleks we observed more pronounced coronary vasodilatation and left ventricle pressure elevation in response to adrenergic heart receptors stimulation by norepinephrine (0.05 − 5.0 mkg, intracoronary). Besides that the drug infusion into coronary blood stream promoted the acceleration of recovery processes of the studied cardiohaemodynamics parameters after norepinephrine injection. After intracoronary infusion of Nucleks the sensitivity of cholinergic receptors to the stimulation by acetylcholine (0.001 − 1.0 mkg, intracoronary) increased significantly. After NO-synthase blockade (L-NAME, infusion 2.0 mg/min, intracoronary) Nucleks did not cause any effect on coronary vessels tone and heart activity both it did not change their adrenergic and cholinergic reactivity.


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