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国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v9.i1.60
pages 47-57

Dependence of the Endocrine Function of Ischemic Ovarian Tissue Transplant on the Lipid Peroxidation Intensity

Victoria V. Kiroshka
Institute for Problems of Cryobiology and Cryomedicine, Kharkiv, Ukraine
Yuliya O. Bozhkova
Institute for Problems of Cryobiology and Cryomedicine, Kharkiv, Ukraine
Iryna A. Trutaieva
Institute for Problems of Cryobiology and Cryomedicine, Kharkiv, Ukraine
Ahmed A. Gawas
Karazin Kharkiv National University, Kharkiv, Ukraine

ABSTRACT

Correlation between endocrine function, morphology, and volume changes in the structure of ovarian tissue, as well as lipid peroxidation intensity at different temperature and time parameters in ischemia modeling were investigated. It has been revealed that the morphological transformations after 2 hours of ischemia at 37°C and 24 hours at 4°C are reversible. In this case, a significant increase in the concentration of sex hormones in animals-recipients is observed relative to castrated ones after heterotopic transplantation. An increase in the duration of ischemia up to 4 hours at 37°C and to 48 hours at 4°C leads to irreversible morphological transformation and failure of endocrine function, except for the tissue incubation (4°C, 48 hours) in a mannitol-containing solution (MCS), where the accumulation level of thiobarbituric acid reactive substances (TBARS) is 2.5–3 times lower. This data correlates with a significant growth of estradiol and progesterone concentrations in recipient animals. Thus, the combined protective effect of hypothermia and mannitol in ischemia has been demonstrated.


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