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国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v6.i1.20
pages 13-22

Changes in Active Lysosomal Cysteine Cathepsins from Thyroid Papillary Carcinoma Tissues with Various Biological Characteristics

Olena V. Kalinichenko
State Institution V.P. Komisarenko Institute of Endocrinology and Metabolism of AMS of Ukraine, Kyiv
Tamara M. Myshunina
V.P. Komisarenko Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Mykola D. Tronko
Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

ABSTRACT

To clarify possible role of cysteine cathepsins H, B and L in the proteolytic processes that contribute to the progression of tumor growth in the thyroid, we studied the activity of the latter in lysosomes isolated from the tissue of papillary carcinoma. It has been shown that changes in the activity of these enzymes depend on a number of biological characteristics of the tumors. In particular, the sharp increase in the activity of cathepsin H is observed in lysosomes from T2 and T3 tissue carcinomas at both intra- and extra-thyroid and lymphatic invasion of tumor cells. An increase in the activity of cathepsin B is detected in lysosomes from the tissue of heterogeneous follicular structure, especially in the presence of solid areas, in comparison with typical papillary tumors, and in the lysosomes from tissue carcinomas at intra-thyroid invasion. An increase in the activity of cathepsin L is observed at extrathyroid invasion. A common feature of cathepsins is an increase in their activity in lysosomes from tissue nonencapsulated papillary carcinomas. These enzymes seem not to contribute to the invasion of tumor cells into blood vessels and to the mechanisms of dissemination of tumor to regional lymph nodes. The latter is evidenced by the absence of changes in the activity of cathepsins in lysosomes from tissue carcinomas category N1. The results obtained indicate the different role of cathepsins H, B and L in thyroid carcinogenesis, where each enzyme has its specifc function.


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