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国际生理学与病理学期刊
SJR: 0.106

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v6.i1.10
pages 1-11

Role of HIF-1 in Neuronal Mechanisms of Adaptation to Psychoemotional and Hypoxic Stress

Elena A. Rybnikova
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Ksenia A. Baranova
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Tatjana S. Gluschenko
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Oleg Vetrovoy
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Maria Sidorova
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Volodymyr I. Portnichenko
International Center for Astronomical, Medical and Ecological Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine; Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

ABSTRACT

Using quantitative immunohistochemistry, neuronal expression of α-subunit of the transcriptional factor HIF-1 was studied in the hippocampus and the neocortex of rats in response to pathogenic psychoemotional stress (model of posttraumatic stress disorder, PTSD) and hypoxic stress (severe hypobaric hypoxia, 180 mm Hg, 3 h), as well as following neuroprotective hypoxic pre- and postconditioning. Prolonged overexpression of HIF-1 α in the hippocampus and the neocortex of rats in response to the psychoemotional stress in PTSD paradigm, but not hypoxic stress, has been observed. Hypoxic pre- and postconditioning with mild hypobaric hypoxia (360 Torr, 2 h, 3 trials spaced at 24 h), which promotes adaptation to the psychoemotional stress, was shown to abolish the prolonged HIF-1 α overexpression. In addition, hypoxic postconditioning up-regulated HIF-1α expression in the brain neurons of rats survived severe hypoxia by improving the structure and functional rehabilitation after severe hypoxic stress. The results obtained indicate that a transcription factor HIF-1 is particularly involved in the processes of adaptation/maladaptation to the action of injurious stresses, but its role depends upon the nature of a stressor.


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