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国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v1.i4.20
pages 315-327

The Association of A−1082G Polymorphism of IL-10 and (A−308G) Polymorphism of TNFα Genes with Bone Density in Elderly Women

Iryna M. Pishel
Institute of Gerontology of the Medical Academy of Sciences of Ukraine, Kyiv
Olga O. Yevtushenko
Institute of Gerontology of the Medical Academy of Sciences of Ukraine, Kyiv
Yuriy I. Leonov
Institute of Gerontology of the Medical Academy of Sciences of Ukraine, Kyiv
Nataliia V. Grygorieva
Chebotarev Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Ukrainian Scientific-Medical Center of Osteoporosis, Kyiv, Ukraine
Tatiana V. Orlyk
Institute of Gerontology of the Medical Academy of Sciences of Ukraine, Kyiv
Dmytro V. Shytikov
Institute of Gerontology of the Medical Academy of Sciences of Ukraine, Kyiv
Vladyslav V. Povoroznyuk
Chebotarev Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Ukrainian Scientific-Medical Center of Osteoporosis, Kyiv, Ukraine
Gennadi M. Butenko
Institute of Gerontology; and Institute of genetic and regenerative medicine AMN of Ukraine, Kyiv

ABSTRACT

We studied the association between bone mineral density and (A −1082G) polymorphism of IL-10 and (A−308G) polymorphism of TNFα genes. SNP-polymerase chain reaction was used. The study failed to find significant association of A−308G TNFα polymorphism and bone state in postmenopausal women. The patients with AA genotype of A−1082G IL-10 gene have significantly lower indices of bone mineral density comparing with G allele carriers (GG/AG). This association remained true for data of bone mineral density of total body, and separate parts of skeleton: lumbar spine, femoral neck, Ward's triangle of total femur. Our study indicates that A−308G polymorphism of TNFα gene is not associated with indices of bone mineral density in postmenopausal women. However, there is strong evidence that women, carriers of AA genotype of A−1082G polymorphism of IL-10 gene have significantly lower indices of bone mineral density. This indicates the potential for predictive genetic testing of osteoporosis risk. Analyses of gene combination IL-10 G−1082G and TNFα G−308G ('antiinflammatory genotype') did not show any significant association of this genotype with bone characteristics, which shows low predictive value of this combination for diagnostics of osteoporosis.


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