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国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v7.i3.50
pages 231-238

Changes in the Brain Testosterone Metabolism and Sexual Behavior of Male Rats Prenatally Exposed to Methyldopa and Stress

Alexander G. Reznikov
V.P.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Nadiya D. Nosenko
V.P.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Larisa V. Tarasenko
V.P.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; Zaporozhye State Medical Academy for Postgraduate Education, Zaporozhye, Ukraine
Anna A. Limareva
Komissarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

ABSTRACT

The changes in aromatase and 5α-reductase activities in the preoptic area (POA) and the medial basal hypothalamus of 10-day-old male rats, and sexual behavior of 3-month- old male rats, offsprings of females exposed to noradrenaline antagonist methyldopa (400 mg/kg per os) 30 minutes prior to 1-hour immobilization during the last week of pregnancy (daily, from 15th to 21st day) were studied. Prenatal stress caused aromatase activity lowering in the POA of developing brain and feminization (appearance of lordosis) and demasculinization of sexual behavior (prolongation of latent periods to the first mounting and first intromission) in young male offspring. Oral methyldopa used prior to stressing of pregnant females prevented early effect of prenatal stress on aromatase activity in the POA and some disorders of the male sexual behavior in young male rats. The data obtained indicate that brain noradrenergic system plays significant role in the mechanisms of metabolic and behavioral disturbances developing in male rats exposed to prenatal stress.