图书馆订阅: Guest
国际生理学与病理学期刊

每年出版 4 

ISSN 打印: 2155-014X

ISSN 在线: 2155-0158

SJR: 0.116

Endothelial Monocyte Activating Factor II Cancels Oxidative Stress and Disorders in Cardiac Hemodynamics Induced by Constitutive NO-Synthase Uncoupling in Hypertension

卷 7, 册 2, 2016, pp. 157-166
DOI: 10.1615/IntJPhysPathophys.v7.i2.70
Get accessGet access

摘要

The study was aimed at investigating the effect of endothelial monocyte activating factor II (EMAP II) on free radical state of the heart and the blood vessels, restoration of cNOS coupling and cardiac hemodynamics in spontaneously hypertensive rats. It has been revealed that EMAP II quickly normalizes impaired in hypertension constitutive de novo synthesis of NO by restoring cNOS coupling due to combined inhibition of oxidative and nitrosative stress. It resulted in improving of the pumping function of the heart (for example, stroke volume increased by 18.2% and cardiac output − by 22%), as well as decreasing the arterial stiffness by 23.2% and improving the left ventricular relaxation due to decreased 4.7 times myocardial end-diastolic stiffness.

1188 文章浏览量 5 文章下载 统计数据
1188 文章浏览量 5 下载次数 Google
Scholar
引用次数

相似内容的文章:

Physical Exercise Training Restores Constitutive NOS Coupling and Cardiac Hemodynamics in Hypertension International Journal of Physiology and Pathophysiology, Vol.7, 2016, issue 3
Vadim F. Sagach, Anatoliy V. Kotsuruba, Bogdan S. Kopyak, Nataliya A. Dorofeyeva
Cardiac Pump Function and Contractility upon β-Adrenergic Hyperstimulation in Rats International Journal of Physiology and Pathophysiology, Vol.2, 2011, issue 4
Mariya O. Kuzmenko, Victoriya B. Pavlyuchenko, Lesya V. Tumanovska, Viktor E. Dosenko, Oleksiy O. Moibenko
Cardiohemodynamics and Efficiency of Frank − Starling Mechanism in Aging International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 4
Konstantin O. Drachuk, Vadim F. Sagach, Nataliya A. Dorofeyeva
Cardiohemodynamics and Efficiency of the Frank-Starling Mechanism in Spontaneously Hypertensive Rats International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 1
Mariya O. Kuzmenko, Vadim F. Sagach, Tetyana V Shimanskaya, Nataliya A. Dorofeyeva
Thymic Hormones, Antioxidant Enzymes and Neurogenesis in Bulbus Olfactorius of Rats with Hemiparkinsonism: Effect of Melatonin International Journal of Physiology and Pathophysiology, Vol.7, 2016, issue 4
H. M. Butenko, A. Ye. Rodnichenko, Vadim F. Sagach, I. A. Kuz'minov, R. H. Vasiliev, O. V. Pod'yachenko, N. O. Utko, Sergiy O. Talanov, Irina F. Labunets, Bogdan S. Kop'yak

最新一期

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain