摘要

The effects of fullerene C₆₀ (FC₆₀) on the levels of free radical and destructive processes in experimental adjuvant arthritis (AA) were studied in rats. Protective effect of FC₆₀ during AA was noted through the reduction of malonidyaldehide concentration increment in the liver (13.44 ± 0.83%) and in the kidneys (18.86 ± 1.36%), an increase in the activities of antioxidant enzyme superoxidedismutase in the liver (15.96 ± 0.38 µmol/kg·s) and kidneys (5.36 ± 0.27 µmol/kg·s), and catalase in the kidneys (9.56 ± 0.78 µmol/kg·s) and the heart (2.26 ± 0.41 µmol/kg·s) in comparison to the control group (43.83 ± 5.69%; 54.55 ± 6.18%; (11.68 ± 0.52) µmol/kg·s; (3.43 ± 0.47) µmol/kg·s; (4.77 ± 0.5) µmol/kg·s; (0.98 ± 0.12) µmol/kg·s, respectively). Protective effect of FC₆₀ in AA was directed on the weakening of destructive processes in the connective tissue as evidenced by the reduction of the total level collagenolitic activity in the cartilage (10.05 ± 0.06 µmol/g/min) and bone (11.21 ± 0.04 µmol/g/min) tissues, free hydroxyproline contents (1.54 ± 0.04 µg/ml) and alkaline phosphatase activity (1.24 ± 0.14 µmol/l·sec) in comparison to control group (11.91 ± 0.49 µmol/g/min; (13.19 ± 0.15) µmol/g/min; (2.25 ± 0.07) µg/ml; (2.19 ± 0.24) µmol/l·s, respectively). Taken together, these results evaluate prospects of future investigations of FC₆₀ − induced effects in rheumatoid arthritis as a feasible therapeutic agent.