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国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v8.i3.80
pages 271-277

Effect of Hydrogen Sulfide Donor on Intraocular Pressure in Rats

Irina N. Mikheytseva
Filatov State Institute of Eye Diseases and Tissue Therapy, National Academy of Medical Sciences of Ukraine, Odessa, Ukraine
T. I. Siroshtanenko
Filatov State Institute of Eye Diseases and Tissue Therapy, National Academy of Medical Sciences of Ukraine, Odessa, Ukraine

ABSTRACT

We studied the effect of 1% sodium hydrosulfide solution (NaHS) on intraocular pressure (IOP) in intact rats and those with simulated ocular hypertension induced by prolonged systemic administration of adrenaline. A single administration of hydrogen sulfide donor as drops into the eye cavity caused the hypotensive effect, which was rather weak in the eyes of intact rats and pronounced in those with ocular hypertension. Long-term administration of NaHS by the scheme, against the background of applying adrenaline as inductor, to a large extent, prevented the IOP rise. It has been concluded that hydrogen sulfide is involved in the regulation of intraocular hydrodynamics and maintaining normal IOP levels.