摘要

Matrix Gla-protein (MGP) gene allelic polymorphism was determined in 170 patients with ischemic atherothrombotic stroke (IATS) and in 124 healthy subjects (control group). It has been shown that in patients with IATS the ratio of main homozygotes, heterozygotes and minor homozygotes is 61.2, 31.2, and 7.6%, respectively, when analyzing T⁻¹³⁸ → C (rs1800802) promoter polymorphism (in the control group, it is 59.7, 35.6, and 4.8%, P = 0.521 by χ²-test); it is 35.9, 48.8, and 15.3% for G⁻⁷ → A (rs1800801) promotor polymorphism (in the controlgroup, it is 43.5, 50.0, and 6.5%, P = 0.051); and it is 39.4, 48.8, and 11.8% for Thr₈₃ → Ala (rs4236) polymorphism of the 4^th exon (in control group, it is 34.7, 53.2, and 12.1%, P = 0.701). Significant difference in the frequency of G⁻⁷ → A polymorphism between the patients with IATS and the control group were revealed only for women (P = 0.022). The results obtained suggest that the A/A-variations of MGP gene promotor (G⁻⁷ → A polymorphism) is associated with an increased risk of IATS in females in Ukrainian population.