图书馆订阅: Guest
国际生理学与病理学期刊

每年出版 4 

ISSN 打印: 2155-014X

ISSN 在线: 2155-0158

SJR: 0.116

Inhibition of Mitochondrial Hydrogen Sulfide Production Worsens Heart Contractility and Enhances Sensitivity of Mitochondrial Permeability Transition Pore to Calcium

卷 9, 册 2, 2018, pp. 135-142
DOI: 10.1615/IntJPhysPathophys.v9.i2.50
Get accessGet access

摘要

We examined the involvement of hydrogen sulfide (H2S) catalyzed by mitochondrial enzyme 3-mercaptopyruvate-sulfurtransferase (3-MST) in cardiac tolerance to calcium load and regulation of mitochondrial permeability transition pore (MPTP) opening. In isolated rat heart, it has been revealed that the enzyme inhibition by O-carboxymethyl hydroxylamine (O-CMH) (50 mg/kg, i.p., 30 min before the experiment start) results in worsening of all heart indices. In particular, the left ventricular developing pressure (LVDP), as well as myocardium contraction/relaxation rate (dP/dt) decreased by 50%. When modeling calcium load, CMH induced a rapid increase in LV end-diastolic pressure and developing of arhythmias. Further modeling of Ca2+ loads was accompanied by lower increment of LVDP and dP/dt comparing to that in control rats indicating low functional reserves and low Ca2+ efficacy in O-CMH-pretreated rats. Cardiac mitochondria in O-CMH group were more sensitive to Ca2+ showing maximum swelling at 10−5 moles/L in the incubation medium vs 10−4 moles/L in control group (p < 0.05). Preincubation of cardiac mitochondria with O-CMH in concentrations of 10−5, 10−4, and 10−3 moles/L evoked an increase in Ca2+ -induced swelling by 17.8, 20, and 44%, respectively. An inhibition of mitochondrial pathway of H2S synthesis increased heart mitochondria sensitivity to Ca2+, which resulted in swelling of mitochondrial membranes and low ability of myocardium to manage Ca2+ homeostasis under Ca2+ loads. Thus, it has been found that endogenous hydrogen sulfide of mitochondrial origin is involved in the regulation of MPTP opening, and also plays an important role in regulating the heart functioning.

1037 文章浏览量 7 文章下载 统计数据
1037 文章浏览量 7 下载次数 Google
Scholar
引用次数

相似内容的文章:

Hydrogen Sulfide Inhibits Calcium-Induced Mitochondrial Permeability Transition Pore Opening in the Heart of Spontaneously Hypertensive Rats International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 4
Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Nataliya A. Dorofeyeva
Effect of NaHS, Hydrogen Sulfide Donor, on the Functional State of the Respiratory Chain in the Rat Heart Mitochondria International Journal of Physiology and Pathophysiology, Vol.5, 2014, issue 2
Nataliya A. Strutynska, Galyna L. Vavilova, Alina Yu. Budko, Vadim F. Sagach, Olena M. Semenykhina
Genipin, the UCP2 Inhibitor, Depresses Heart Function of Aging Rats International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 2
Yulia V. Goshovska, Vadim F. Sagach, Tetyana V Shimanskaya
Increased Sensitivity of Mitochondrial Permeability Transition Pore to Ca2+ in the Heart of Spontaneously Hypertensive Rats International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 3
Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Nataliya A. Dorofeyeva
Hydrogen Sulfide Inhibits Calcium-Induced Mitohondrial Permeability Transition Pore Opening in the Heart of Adult and Old Rats International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 2
Snizhana V. Chorna, Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Olena M. Semenykhina

最新一期

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain