摘要

In a study of the renal function under cisplatin chemotherapy in oncologic patients, nephrotoxicity of the drug has been confirmed. It was found that diuresis and creatinine excretion, sodium, potassium, osmotically active substances and chlorides increased more than twice in 24 h after a dose of 50 mg/m² of the body surface, which constitutes a disorder in osmolarity, volume and ionic regulation of the renal function. The determined features are the result of a damage to the kidneys, which is confirmed by an increase in erythro-and leucocyteuria. It has been shown that a disorder in the homeostatic renal function is due to renal tubular damage against an increase in glomerular filtration rate. Renal protection during cisplatin chemotherapy throughout the course of the treatment has been proved to be necessary.