图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v3.i2.70
pages 175-184

Effects of Cytokine-Like Polypeptide EMAP II and Flutamide on Testosterone-Stimulated Prostate of Castrated Rats

Alexander G. Reznikov
V.P.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
L. V. Chaikovskaya
VP.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
L. I. Polyakova
VP.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Olga V. Sachynska
Komissarenko Institute of Endocrinology and Metabolism, Kyiv, Ukraine; Zaporozhye State Medical Academy for Postgraduate Education, Zaporozhye, Ukraine

ABSTRACT

The effects of separate and combined administration of cytokine-like polypeptide EMAP II and flutamide, a non-steroid antiandrogen, on morphologyy and function of the accessory sexual glands in castrated immature male rats stimulated with testosterone propionate were studied. Anti-androgenic, pro-apoptotic, and pro-coagulating effects of EMAP II have been revealed in the ventral prostate. Combined use of the drugs resulted in enhanced anti-prostatic effects capable of inhibiting the processes of proliferation and apoptosis, as well as DNA, RNA and protein contents. Combined use of EMAP II and flutamide may be useful in developing new therapeutic modalities in prostate cancer.


Articles with similar content:

Development of Gene-Based Therapies for Cartilage Repair
Critical Reviews™ in Eukaryotic Gene Expression, Vol.12, 2002, issue 4
Paul D. Robbins, Oliver Betz, Arnulf Pascher, Christopher H. Evans, Steven C. Ghivizzani, Glyn Palmer, Myron Spector, Jean-Noel Gouze, Elvire Gouze
Dietary Flavonoid and Cancer Prevention: Evidence and Potential Mechanism
Critical Reviews™ in Oncogenesis, Vol.8, 1997, issue 1
Shiu-Ming Kuo
Calcium-Sensing Receptor Arbitrates Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells via the G Protein-PLC-IP3 Pathway
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 1
Zhengying Duan, Ting Gao, Zuowu Jiao, Wei Liu, Yongxiang Tian, Keli Yang, Hui Zhang, Khalid Mehmood, Zhenyu Chang, Fangyan Yuan, Zewen Liu, Muhammad Taslim Ghori, Xiaoying Pei, Rui Guo, Muhammad Ijaz
Stem Cell Marker OCT3/4 in Tumor Biology and Germ Cell Tumor Diagnostics: History and Future
Critical Reviews™ in Oncogenesis, Vol.12, 2006, issue 3-4
Jeroen de Jong, Leendert H. J. Looijenga
Cyclooxygenase-2: Molecular Biology, Pharmacology, and Neurobiology
Critical Reviews™ in Neurobiology, Vol.13, 1999, issue 1
M. Kerry O'Banion