图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v3.i2.60
pages 161-173

Endothelium-Derived Hyperpolarizing Factor as a Reserve Defense Mechanism of the Vascular Control under Ionizing Radiation Impact

Irina V. Ivanova
Institute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Olga V. Kislova
Institute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Anatoly I. Soloviev
Institute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

ABSTRACT

Membrane mechanisms underlying γ-radiation-induced changes in the contractile activity of the blood vessels were studied. The results obtained indicate that an exposure to γ-radiation inhibits the endothelium-dependent relaxation of isolated segments of the rat thoracic aorta due to a significant decrease in NO-component, while the component dependent on endothelial hyperpolarizing factor (EDHF) remains practically unchanged. This fact is confirmed by determining nitrites, NO metabolites: concentration of acetylcholine-stimulated nitrite anion derived by the aorta of exposed to γ-rays rats was significantly lower compared to the controls. Experiments on isolated rat aortic smooth muscle cells using whole-cell patch clamp technique demonstrated that irradiation resulted in a significant decrease in total outward potassium currents. However, an exposure to γ-radiation was without effect on K+-current through apamine-sensitive potassium channels, whereas the current through charybdotoxin-sensitive channels was significantly increased. The data suggest that EDHF is resistant to ionized radiation and may constitute a crucial reserve mechanism to maintain the blood flow under radiation. Therefore, it is likely that the subsequent studies related to EDHF identification will be important for new drug development and targeted pharmacological intervention at endothelium dysfunction in case of radiation impact.


Articles with similar content:

Vasodilatation Effects of Fluorine- Containing KATP Channels Opener of Flocalin
International Journal of Physiology and Pathophysiology, Vol.2, 2011, issue 1
Ruslan B. Strutynskyi
Effects of Genipin at NO synthesis and Ischemia-Reperfusion Induced Oxidative Stress in Old Rat Hearts
International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 4
Yulia P. Korkach, Yulia V. Goshovska, Vadim F. Sagach, Anatoliy V. Kotsuruba, Tetyana V Shimanskaya
The Effect of Lomg-Term Exercise Training on the Changes in the Functional State of Heart duringIschemia-Reperfusion, the Sensitivity of Calcium- Induced Mitochondrial Permeability Transition Pore and the Uncoupling Protein 3 Expression
International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 3
Snizhana V. Chorna, Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, N. M. Gaidai, Sergiy O. Talanov
Mitochondria as a Target of Intermittent Hypoxia
International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 4
Tetyana V. Serebrovska, Iryna N. Mankovska
Amphetamine Neurotoxicity: Cause and Consequence of Oxidative Stress
Critical Reviews™ in Neurobiology, Vol.17, 2005, issue 2
Bryan K. Yamamoto, Michael G. Bankson