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国际生理学与病理学期刊

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ISSN 打印: 2155-014X

ISSN 在线: 2155-0158

SJR: 0.116

Changes in mRNA and Protein Expression of Antioxidant Enzymes in Leukocytes of Children with Bronchial Asthma after Interval Hypoxic Training

卷 3, 册 2, 2012, pp. 125-134
DOI: 10.1615/IntJPhysPathophys.v3.i2.30
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摘要

The impact of a 10-day-long interval hypoxic training (IHT) on the level of mRNA expression and protein content of the antioxidant enzymes (superoxide dismutase, catalase, and glutathione-S-transferase) in the leukocytes of the children suffering from bronchial asthma was studied. It has been found that IHT induced a decrease in mRNA expression of superoxide dismutase by 32.5% (P < 0.05), whereas protein content remained unchanged. The level of catalase gene mRNA and protein content in the leukocytes increased by 67% and 13%, respectively. An increase in protein amount of glutathione-S-transferase by 90% (P < 0.05) has been shown compared with this before training.

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