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国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v3.i2.80
pages 187-208

Structure and Function of Biological Membranes: The Impact of Nanoparticles

Ivan S. Chekman
National Institute of Physical Education and Sport, Kyiv, Ukraine
Pavel V. Simonov
Bogomolets National Medical University, Kyiv, Ukraine

ABSTRACT

The current views on the structure and function of biological membranes, the role of their lipid, protein and carbohydrate components in the maintenance of cell vital activity are summarized. The up-to-date model of a biological membrane structure as nanocompartmentalized fluid in which lipids and proteins undergo anomalous diffusion has been examined. An attention is paid to the theory of the lipid raft existence as nanoscale membrane domains. The analysis of literature and research results on the nanonature of ion channels, patterns of nanoparticle effects on the biological membrane has been carried out. The data on the structure and function of a biological membrane and the impact of nanoparticles on it are basic to create new highly therapeutic and diagnostic agents, and to study the toxicological properties of nanoobjects.


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