图书馆订阅: Guest
国际生理学与病理学期刊

每年出版 4 

ISSN 打印: 2155-014X

ISSN 在线: 2155-0158

SJR: 0.116

Calcium Signals Induced By Tonic Firing In Rat Retinal Ganglion Cells

卷 3, 册 1, 2012, pp. 53-59
DOI: 10.1615/IntJPhysPathophys.v3.i1.60
Get accessGet access

摘要

On rat retinal preparation in whole-cell mode retinal ganglion cells (RGC) tonic firing induced calcium signals were recorded and their modulation by Kv3 potassium channels was studied. RGC depolarization with 500 ms current steps caused tonic action potentials (AP) generation and development of calcium signals which amplitude depended quite linearly on mean AP frequency with mean slope (1.4 ± 0.2) s·nmol/l (n = 5). The calcium signals mean tau of decay value was (6.8 ± 1.4) s (n = 5). After application of tetraethylammoniun (500 µM), which in such a concentration blocks Kv3.1/Kv3.2 potassium channels, decreasing of firing frequency, increasing of AP width and decreasing of fast afterhyperpolarization amplitude were observed. In the blocker presence the calcium signal amplitude vs mean AP frequency dependency slope mean value increased to (2.1 ± 0.3) s·nmol/l. The calcium signals decay not changed significantly, the mean value was (6.8 ± 1.4) s (n = 5). Thus, voltage-dependent Kv3.1/Kv3.2 potassium channels, which play a key role in tonic firing pattern generation in RGC, also modulate appropriate calcium signals and prevent the cells from significant intracellular calcium increasing and its possible cytotoxic action.

参考文献
  1. Veselovskaya ZF, Veselovskaya NN. , Comparative efficacy of Norvasc and Amlodipine on the base of the results of dynamic changes in objective parameters of the functional status of the macular area of the retina in patients with open angle glaucoma and nonproliferative diabetic retinopathy.

  2. Luk'ianets' OO, Iavors'kyi VA. , The action of pilocarpine on the accommodation properties of isolated phasic neurons of the rat hippocampus.

  3. Cheung W, Guo L, Cordeiro MF. , Neuroprotection in glaucoma: drug-based approaches.

  4. Henne J, Jeserich G. , Maturation of spiking activity in trout retinal ganglion cells coincides with upregulation of Kv3.1- and BK-related potassium channels.

  5. Grynkiewicz G, Poenie M, Tsien RY. , A new generation of Ca2+ indicators with greatly improved fluorescence properties.

  6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X. , International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

  7. Mann M, Haq W, Zabel T, Guenther E, Zrenner E, Ladewig T. , Age-dependent changes in the regulation mechanisms for intracellular calcium ions in ganglion cells of the mouse retina.

  8. O'Brien BJ, Isayama T, Richardson R, Berson DM. , Intrinsic physiological properties of cat retinal ganglion cells.

  9. Rudy B, McBain CJ. , Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing.

  10. Wang GY, Robinson DW, Chalupa LM. , Calcium-activated potassium conductances in retinal ganglion cells of the ferret.

对本文的引用
  1. Wang Lei, Liang Pei-Ji, Zhang Pu-Ming, Qiu Yi-Hong, Ionic mechanisms underlying tonic and phasic firing behaviors in retinal ganglion cells, Channels, 8, 4, 2014. Crossref

622 文章浏览量 6 文章下载 统计数据
622 文章浏览量 6 下载次数 1 Crossref 引用次数 Google
Scholar
引用次数

相似内容的文章:

Calcium Signals Induced by Tonic Firing in the Rat Retinal Ganglion Cells International Journal of Physiology and Pathophysiology, Vol.2, 2011, issue 4
Vitally Y. Maslov, Mycola S. Veselovsky, Kyryl I. Kuznetsov, Svetlana A. Fedulova
Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 4
N. Ya. Martyniuk, V. Yu. Maslov, Nikolai S. Veselovsky, Helen E. Purnyn, Svetlana A. Fedulova
Pulse-Modulated Information Wave Therapy in Complex Treatment of Cerebral Atherosclerosis Patients with Minimal Neurological Deficiency Telecommunications and Radio Engineering, Vol.57, 2002, issue 8-9
G. A. Chukanova, G. I. Doroshenko, V. V. Malakchov, Boris Ivanovich Makarenko
Modulating Effect of Peptide Semax on the Level of Synaptic Activity and Short-Term Plasticity in Glutamatergic Synapses of Co-Cultured Dorsal Root Ganglion and Dorsal Horn Neurons of Rats International Journal of Physiology and Pathophysiology, Vol.7, 2016, issue 3
Mariia S. Shypshyna , Mycola S. Veselovsky, Nikolai F. Myasoedov, Stanislav I. Shram, Svetlana A. Fedulova
Effect of β-amyloid Peptide on Plasmalemmal Calcium Channels in Cultured Hippocampal Neurons International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 1
Elena P. Kostyuk, Tatyana Yu. Korol, Platon G. Kostyuk

最新一期

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain