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国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v2.i2.40
pages 133-140

Influence of the Inhibitor of Nf-KB Activation, Curcumin, on the Oogenesis and Follicular Cell Death under Immune Ovarian Failure in Mice

Tetyana Yu. Voznesenska
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tetyana M. Bryzgina
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Vera S. Sukhina
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Nataliya V. Makogon
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Irina N. Alexeyeva
Department of Immunology and Cytotoxic Sera, Bogomoletz Institute of Physiology, Kyiv, Ukraine

ABSTRACT

In experiments on CBA mice, we studied an influence of an inhibitor of nuclear transcription factor kB activation curcumin, obtained from Curcuma longa, on the meiotic maturation of oocytes and apoptotic and necrotic death of follicular cells at immune ovary failure induced by immunization of animals with allogenic ovarian extracts. NF-kB plays a pivotal role in the induction of genes encoding pro- inflammatory factors (cytokines, adhesion molecules, inducible NO- synthase and cyclooxygenase) and in regulation of cell proliferation and death. It has been shown that immunization of mice increased the death of follicular cells through a apoptotic and necrotic pathways, which led to inflammatory response (according to leukogramom of the oocytes at metaphase I and II). Intragastric administration of curcumin (Sigma, USA, 2mg of the mouse weight, four times a week during the period of immunization) reduced the number of the follicular cells, died through apoptotic and especially necrotic path-way. It attempted inflammatory response and improved the meiotic maturation of oocytes im-paired under experimental immune ovarian failure in mice.


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