图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v7.i4.60
pages 341-347

Effect of Neonatal Seizures on the Synaptic Plasticity of Rat Somatosensory Cortex

Olena V. Isaeva
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Olexander O. Lunko
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Artur K. Romanov
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Dmytro S. Isaev
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

ABSTRACT

Using an experimental model of neonatal recurrent seizures, we investigated the influence of epileptic seizures on the various forms of synaptic plasticity in neurons of the somatosensory cortex. We have found that early seizures do not affect the post-tetanic potentiation of the amplitude of the postsynaptic potentials and the depression of postsynaptic potentials during high-frequency stimulation. However, they result in the chronic increase in the long-term potentiation of synaptic transmission. The changes in synaptic plasticity may affect the processing of the sensory information in patients with a history of recurrent seizures during early development.