生物,工程和医学的道德
ISSN 打印: 2151-805X
ISSN 在线: 2151-8068
SJR:
0.123
Crossing the Germline Barrier: The Three Genome Baby
卷 6,
册 3-4, 2015,
pp. 237-261
DOI: 10.1615/EthicsBiologyEngMed.2016016331
摘要
The moral boundary separating somatic cell genetic modification and germline genetic modification has been in effect for over 30 years. Recently, with the introduction of nuclear DNA transplantation and gene editing, and with the rising interest in preventing the transfer of certain deleterious genes to newborns, that moral boundary has been called into question. The paper discusses the origins of the somatic cell and germline moral distinction and explores new initiatives to undertake genetic modification of gametes or embryos.
键词: gene editing, germline, somatic cell genetic modification, Asilomar, CRISPR, ooplasmic transfer, mitochondrial disease, nuclear genome transplantation
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