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国际药用蘑菇期刊

每年出版 12 

ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Neurotropic Effect of Extracts from the Hallucinogenic Mushroom Psilocybe cubensis (Earle) Sing. (Agaricomycetideae). In Vitro Studies

卷 2, 册 4, 2000, 10 pages
DOI: 10.1615/IntJMedMushr.v2.i4.130
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摘要

The neurotropic effect of Psilocybe cubensis (Earle) Sing, dried biomass and fruiting bodies containing the indole hallucinogens psilocybin and psilocine on spike activity of pyramidal neurons from the rat hippocampal CAl region slices has been studied. Extracellularly responses of 50 neurons were recorded, 34 during the application of biomass extract (BME) and 16 during the application of fruiting body extract (FBE). Of the total number of cells studied, the inhibition resulting from BME and FBE application was observed in 73.5% and 81% of cells, respectively. Inhibition parameters during the BME and FBE application were (in seconds) as follows: latency 59 ± 7 and 67 ± 8 and duration 251 ± 26 and 273 ± 37, respectively. Only 5.9% of neurons showed excitation resulting from BME application and no excitative response was observed during FBE application. During the BME and FBE application a short burst occurred in 29% and 12.5% of neurons, respectively. Ritancerin (antagonist of 5-HT2/5-HT1C serotonin receptors) blocked inhibitory responses resulting from BME and FBE application in half of the units tested. The duration of response to serotonin could reach 10−43 min whereas the response to extract application usually did not exceed 4−5 min. Extract application inhibited excitation spike responses resulting from L-glutamic acid application. Results that have been obtained show that the application of psilocybin-containing extracts from mushroom fruiting bodies and biomass causes a similar inhibition pattern of spike activity in pyramidal neurons from the hippocampal CA1 region and inhibits excitation of these neurons caused by L-glutamic acid.

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