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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Hepatoprotective Effects of Waxy Brown Rice Cultured with Agrocybe cylindracea (DC.) Gillet

卷 7, 册 3, 2005, pp. 351-352
DOI: 10.1615/IntJMedMushrooms.v7.i3.140
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摘要

The hepatoprotective effects of functional rice, produced by cultured Agrocybe cylindracea (Agarico-mycetideae) on waxy brown rice, were investigated. After oral administration of the methanol extracts of functional rices for 14 days, rats were treated with carbon tetrachloride to induce hepatotoxicity. The enzyme activities were determined, and biochemical analyses of serum were carried out in order to examine the hepatoprotective effects exerted by the samples. A histological study on liver tissue using electron microscope was also conducted.
The body weights and internal organs weights of the rats were measured. The body weight of the group treated with only CCl4 increased less than those of the groups fed with sample extracts prior to CCl4 treatments. The weight of internal organs among the treatment groups did not show substantial difference except that the hepatic hypertrophy was observed in the group treated only with CCl4 . On the other hand, the COCIII group and the CIC groups administered with the methanol extracts from the waxy brown rice and cultured with A. cylindracea, respectively, showed an organ weight similar to that of the normal group.
The activity of serums AST and ALT of rats increased highly in the group treated with CCl4 only. The COC and CIC groups showed a strong suppression on the AST and ALT augmentation almost to the level of normal rats without CCl4 treatment. In particular, the CICII and CICIII groups were able to maintain both the AST and ALT activity in a manner similar to the normal group without CCl4 treatment, and was statistically not significant.
The activity of serums ALP, LDH, and Υ-GPT was significantly increased by carbon tetrachloride treatment, but methanol extracts of brown rice, cultured with A. cylindracea, significantly decreased the activity of those emzymes, which was supposed to be increased by the carbon tetrachloride treatment. CICII and CICIII groups especially demonstrated a strong protective effect by suppressing the increase of these enzymes.
The control group treated only with CCl4 showed a severe decrease in albumin level, total protein, and HDL-cholesterol content in comparison with the normal group. The COC group and the CIC group considerably alleviated the decrease of those components. The content of total cholesterol, triglyceride in liver was increased by administration of CCl4. However, the COC and CIC groups did not show the increases and kept them at almost the same level as the normal rats without CCl4 treatment.
The content of lipid peroxide in the CCl4-treated group significantly increased in comparison with the normal group, but the COCIII and CIC groups had a tendency to maintain lipid peroxide content at a much lower level.
The liver tissue of rats was observed by transmission electron microscope. The injury range of cells was shown to be widest in the control group treated with CCl4 only. In groups administered with the extracts from waxy brown rice cultured with Coprinus comatus (Mull.:Fr.) S.F.Gray and C. cinereus (Schaeff.: Fr.) S.F.Gray prior to CCl4 treatment, diminished lipid degeneration and infiltration of local inflammation caused by CCl4 were alleviated considerably. In particular, the CICIII group showed almost the same integrity as normal rats without CCl4 treatment.

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