图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v17.i2.60
pages 151-160

Immunomodulatory Activities on RAW 264.7 Macrophages of a Polysaccharide from Veiled Lady Mushroom, Dictyophora indusiata (Higher Basidiomycetes)

Haitian Fu
School of Pharmaceutics Science, Jiangnan University, Wuxi 214122, People's Republic of China
Chao Deng
Wuxi Medical School, Jiangnan University, Wuxi 214122, People's Republic of China
Liping Teng
Wuxi Medical School, Jiangnan University, Wuxi 214122, People's Republic of China
Li Yu
School of Pharmaceutics Science, Jiangnan University, Wuxi 214122, People's Republic of China
Tong Su
Wuxi No. 2 People's Hospital, Wuxi 214002, People's Republic of China
Xin Xu
Wuxi No. 2 People's Hospital, Wuxi 214002, People's Republic of China
Jinghua Chen
School of Pharmaceutics Science, Jiangnan University, Wuxi 214122, People's Republic of China
Chengjian Yang
Wuxi No. 2 People's Hospital, Wuxi 214002, People's Republic of China

ABSTRACT

A water-soluble polysaccharide named DI was extracted from the fruiting bodies of gastroid mushroom Dictyophora indusiata with boiling water. The chemical and physical characteristics of DI were investigated by a combination of chemical and instrumental analysis methods. The immunomodulatory activities on RAW 264.7 macrophage of DI in vitro were also studied. The results showed that DI is a β-(1→3)-glucan with side branches of β-(1→6)-glucosyl units, and it has triple-helical structure. DI has no toxic effect on cells, but can promote macrophage multiplication. DI significantly affects the immune function by promoting the production of nitric oxide and cytokines, such as tumor necrosis factor-α, interleukin-1, -6, and -12, showing an obvious dose-effect relationship. This work extends the application scope of the polysaccharide from D. indusiata in the biomedical field.


Articles with similar content:

Anti β-Glucan Antibody in Cancer Patients (Preliminary Report)
International Journal of Medicinal Mushrooms, Vol.6, 2004, issue 1
Yoshiyuki Adachi, Osamu Mizukami, Noriko N. Miura, Naohito Ohno, Ken-Ichi Ishibashi, Masuro Motoi
Cooperative Effect of the Lipopolysaccharide and Culinary-Medicinal Cauliflower Mushroom Sparassis crispa (Wulf.) Fr. (Aphyllophoromycetideae)-Derived β-Glucan on Inflammatory Cytokine Secretion by the Murine Macrophage Cell Line
International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 1
Ha Won Kim, Sung In Kim, In Soo Ko, Hyuk Gu Park, Gye Hyung Cho
Immunomodulating Activity of Bjerkandera sp.
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Mark M. Shamtsyan, Valentina G. Konusova, Alexander M. Goloschev, Natalia V. Pigareva, Arina V. Korchmaryova
Antitumor Effect of Culinary-Medicinal Oyster Mushroom, Pleurotus ostreatus (Jacq.: Fr.) P. Kumm., Derived Protein Fraction on Tumor-Bearing Mice Models
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 5
Mohitosh Mandal, Birendra Behera, Sujit Kumar Bhutia, Swatilekha Maiti, Tapas K Maiti, Sanjaya Kumar Mallick
Specificity of the Immunomodulating Activity of Sasa veitchii (Japanese Folk Medicine Kumazasa) to Fungal Polysaccharides
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 5
Masamichi Tsuboi, Kazuo Takeshita, Masato Kanamori, Yoshiyuki Adachi, Noriko N. Miura, Wataru Sato, Naohito Ohno, Ken-Ichi Ishibashi