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国际药用蘑菇期刊

影响因子: 1.357

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushr.v3.i1.50
4 pages

Ganoderma lucidum (Curt.: Fr.) P. Karst. and G. lipsiense (Batsch) Atk. Do Not Induce Micronuclei in Cultured Human Lymphocytes

Marie-Daniele Steinmetz
Laboratoire de Botanique, Cryptogamie et Biologie Cellulaire, Faculte de Pharmacie, 27 bd Jean Moulin-13385 Marseille Cedex 05, France
Jean-Pierre Rascol
Laboratoire de Botanique, Phytochimie et Mycologie, Faculte de Pharmacie, 15 Avenue Charles-Flabault-34060 Montpellier, France
Irene Sari-Minodier
Laboratoire de Biogenotoxicologie et Mutagenese Environnementale (UPRES EA-1784), Faculte de Medecine, 27 bd Jean Moulin-13385 Marseille Cedex 05, France
Thierry Orsiere
Laboratoire de Biogenotoxicologie et Mutagenese Environnementale (UPRES EA-1784), Faculte de Medecine, 27 bd Jean Moulin-13385 Marseille Cedex 05, France
Claude Andary
Faculty of Pharmacy, University of Montpellier 1.15 Av. Ch. Flahault, 34060, Montpellier Cedex 2, France
Patrick Regli
Laboratoire de Botanique, Cryptogamie et Biologie Cellulaire, Faculte de Pharmacie, 27 bd Jean Moulin-13385 Marseille Cedex 05, France
Alain Botta
Laboratoire de Biogenotoxicologie et Mutagenese Environnementale (UPRES EA-1784), Faculte de Medecine, 27 bd Jean Moulin-13385 Marseille Cedex 05, France

ABSTRACT

Two Ganoderma species (G. lucidum and G. lipsiense, Ganodermatales) are regarded as popular remedies in Chinese and Japanese traditional medicine and their effectiveness seems to be reasonably acceptable. The cytokinesis-blocked micronucleus assay performed in vitro on human lymphocytes for several concentrations of crude extracts shows that these two mushroom species do not exhibit genotoxic properties (clastogenicity and/or aneugenicity). Moreover, no cytotoxic effect was detected at any dose.