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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Changes in Immunomodulating Activities and Content of Antitumor Polysaccharides During the Growth of Two Medicinal Mushrooms, Lentinus edodes (Berk.) Sing, and Grifola frondosa (Dicks.: Fr.) S. F. Gray

卷 3, 册 1, 2001, 7 pages
DOI: 10.1615/IntJMedMushr.v3.i1.10
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摘要

The immunomodulating effects of the growing medicinal mushrooms Lentinus edodes and Grifola frondosa on tumor necrosis factor-α (TNF-α) and nitric oxide (NO) production from murine peritoneal macro-phages were investigated. The weight of the L. edodes fruiting body in this study increased from 9 g to 18 g during growth, and that of G. frondosa increased from 130 g to 200 g. L edodes increased TNF-α production from approximately 500 pg/ml to 700 pg/ml and NO production from 4 μM to 7 μM. Thereafter, it finally decreased TNF-α levels to 500 pg/ml and NO to 5 μM through the growth periods. The growing G. frondosa increased TNF-α production from approximately 300 pg/ml to 500 pg/ml, which finally decreased to 260 pg/ml. NO production increased from 5 to 7 μM, and finally declined to 4 μM during growth. Moreover, to clarify whether these changes in immunomodulating activities of the two mushrooms resulted from changes in antitumor polysaccharides, we examined the contents of lentinan in L. edodes and glucan in G. frondosa (GGF) in the growing mushrooms, respectively, by enzyme-linked imnuinosorbent assay (ELISA). The content of lentinan increased to 1.5 mg/g fresh weight (f.w.), and thereafter finally decreased to 1.1 mg/g f.w. during growth of L. edodes. The content of GGF increased to 2.7 mg/g f.w., but finally decreased to 1.3 mg/g f.w. during growth of G. frondosa. These results suggested that a suitable period in which to harvest the mushroom at its peak antitumor activity was found.

对本文的引用
  1. Minato K.I., Abe C., Immunomodulating Effect of Polysaccharide, in Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, 2013. Crossref

  2. Kim Young-Kyung, Iwahashi Hitoshi, Properties of Polysaccharides Extracted fromPhellinus LinteusUsing High Hydrostatic Pressure Processing and Hot Water Treatment, Journal of Food Process Engineering, 38, 2, 2015. Crossref

  3. Koo Chang-Duck, Cho Sun-Young, Relationship between Water Content and Osmotic Potential ofLentinula edodes, Mycobiology, 36, 1, 2008. Crossref

  4. Moradali Mohammad-Fata, Mostafavi Hossein, Ghods Shirin, Hedjaroude Ghorban-Ali, Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi), International Immunopharmacology, 7, 6, 2007. Crossref

  5. Zhang Yangyang, Li Sheng, Wang Xiaohua, Zhang Lina, Cheung Peter C.K., Advances in lentinan: Isolation, structure, chain conformation and bioactivities, Food Hydrocolloids, 25, 2, 2011. Crossref

  6. Minato Ken-ichiro, Mushrooms: Immunomodulating Activity and Role in Health Promotion, in Dietary Components and Immune Function, 2010. Crossref

  7. Barros Ana, Bell Vitoria, Ferrão Jorge, Calabrese Vittorio, Fernandes Tito, Mushroom Biomass: Some Clinical Implications of β-Glucans and Enzymes, Current Research in Nutrition and Food Science Journal, 4, Special-Issue-Oc, 2016. Crossref

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