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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.2019030638
pages 493-502

Taking Ingredients as an Entry Point to Explore the Relationship between the Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), and Diabetes Mellitus (Review)

Hui Cao
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Shiyuan Wang
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Xiaowei Cui
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Hong Guo
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Xiaozhi Xi
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Fangxue Xu
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Yujuan Li
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Mengmeng Zheng
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Chunchao Han
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China

ABSTRACT

Diabetes mellitus (DM) is a common endocrine and metabolic disease caused by protein and fat metabolism disorders as the main clinical manifestation due to the relative or absolute deficiency of insulin secretion in the body. Despite significant prevention and treatment efforts, the number of people with DM is still increasing. A safe and effective resource to prevent and treat DM is urgently needed. In recent years, many reports have indicated that medicinal mushrooms have a hypoglycemic effect. Among them, Coprinus comatus has great potential for development as a hypoglycemic drug or food; it is an emerging medicinal and edible fungus with a variety of nutrients (polysaccharides, unsaturated fatty acids, dietary fibers, vitamins, trace elements, amino acids, etc.). These ingredients have been closely linked to the hypoglycemic effects of C. comatus, possibly by increasing insulin release, protecting islet cells from invasion, enhancing antioxidant activity, regulating metabolic pathways, and reducing inflammation. This review preliminarily summarizes the hypoglycemic effect of C. comatus by introducing the ingredients it contains, which can provide theoretical support for the development of C. comatus as a potential hypoglycemic resource.


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