每年出版 12 期
ISSN 打印: 1521-9437
ISSN 在线: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
The Nature of Apoptosis of Human Breast Cancer Cells Induced by Three Species of Genus Ganoderma P. Karst. (Aphyllophoromycetideae) Crude Extracts
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摘要
The cytotoxic effect of crude extracts of three Ganoderma species (G. lucidum, G. tropicum, and G. tsugae) was screened against the human estrogen-independent cell line, MDA-MB-435 using a microculture tetrazolium (MTT) assay. The crude extract obtained from the fruiting body of Ganoderma lucidum by hot water extraction procedures had IC50 values ranging from 140 to 350 μg mL−1. Acridine-orange/propidium iodine staining, electron microscopy, and transmission electron microscopy showed that the crude extract caused both apoptosis and necrosis. The G. lucidum mycelial crude extract was most effective, with an IC50 value of 148 μg mL−1.
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Tong Chow-Chin, Choong Yew-Keong, Umar Nor-Aini-B, Noordin Mohamed-Mustapha, Mohamed Suhaila, Cytotoxic activity induced by crude extracts of Ganoderma lucidum (W. Curt.: Fr.) P. Karst. on mouse myeloma cancer cell-line, World Journal of Microbiology and Biotechnology, 25, 4, 2009. Crossref
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Li Ya, Li Sha, Meng Xiao, Gan Ren-You, Zhang Jiao-Jiao, Li Hua-Bin, Dietary Natural Products for Prevention and Treatment of Breast Cancer, Nutrients, 9, 7, 2017. Crossref
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Iqbal Javed, Abbasi Banzeer Ahsan, Batool Riffat, Mahmood Tariq, Ali Barkat, Khalil Ali Talha, Kanwal Sobia, Shah Sayed Afzal, Ahmad Riaz, Potential phytocompounds for developing breast cancer therapeutics: Nature’s healing touch, European Journal of Pharmacology, 827, 2018. Crossref