图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v1.i3.10
pages 195-206

A Review of Pharmacological Activities of Mushroom Polysaccharides

Vincent Eng Choo Ooi
Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories Hong Kong, China
Fang Liu
Department of Microbiology, College of Life Science, Nankai University, Tianjin, China

ABSTRACT

In the last few decades, mushrooms have increasingly been used as a source of therapeutic agents or health food supplements. In particular, polysaccharides or polysaccharide-protein complexes derived from mushrooms have received much attention in biomedical research. These bioactive biopolymers are mainly present as glucans with different types of glycosidic linkages, such as (1→3), (1→6)-β-glucans and (1→3)-α-gtucans, while others mostly bind to protein residues as polysaccharide-protein complexes. One of the most promising activities of these polysaccharides is their immunomodulation and anticancer effect. Three antitumor polysaccharides, namely lentinan, schizophyllan, and protein-bound polysaccharide (or polysaccharopeptide), have been isolated from Lentinus edodes (Berk.) Sing., Schizophyllum commune (Fr.: Fr.), and Coriolus versicolor (L.: Fr.) Quel. [= Trametes versicolor (L.: Fr.) Lloyd], respectively, and have become large nutraceutical and pharmaceutical market items, particularly in Japan. The mechanism of their antitumor actions is still not completely understood. But it is widely accepted that antitumor polysaccharides from higher fungi enhance various immune responses in vivo and in vitro, and act as biological response modifiers. Potentiation of the host defense system may result in the activation of many kinds of immune cells that are vitally important for the maintenance of homeostasis. In addition to immunomodulation and antitumor activity, there are new potential applications of mushroom polysaccharides or polysaccharide-protein complexes for pharmaceutical and functional food development. These polysaccharides have been shown to have various potent pharmacological properties, such as antioxidant, free radical scavenging, antiviral, hepatoprotective, antifibrotic, antiinflammatory, antidiabetes, and hypocholesterolemic activities.


Articles with similar content:

Therapeutic Effects of Substances Occurring in Higher Basidiomycetes Mushrooms: A Modern Perspective
Critical Reviews™ in Immunology, Vol.19, 1999, issue 1
Solomon P. Wasser, Alexander L. Weis
Biotechnological Potential of Mushrooms: Drugs and Dye Production
International Journal of Medicinal Mushrooms, Vol.8, 2006, issue 4
Girish Tidke, Mahendra K. Rai
Medicinal Properties of Substances Occurring in Higher Basidiomycetes Mushrooms: Current Perspectives (Review)
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 1
Solomon P. Wasser, Alexander L. Weis
Antioxidant and Immunomodulating Activities of Exo-and Endopolysaccharide Fractions from Submerged Mycelia Cultures of Culinary-Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 3
Karthik Marripudi, Cheang Khoo, Sundar Rao Koyyalamudi, Jong Pil Park, Jin Hee Kim, Sang-Chul Jeong, Chi-Hyun Song, J. Margaret Hughes, Trevor Bailey
Study of Antiprotozoal Activity and Mitogenic Effects Within Some Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
S. H. Sisakyan, Susanna M. Badalyan