每年出版 12 期
ISSN 打印: 1521-9437
ISSN 在线: 1940-4344
Indexed in
Antinociceptive Activity of Agaricoglycerides Extracted from Mycelium of Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae)
摘要
The antinociceptive activity of agaricoglycerides extracted from mycelium of Ling Zhi or Reishi medicinal mushroom, Ganoderma lucidum (AMG) was studied. The writhing test, formalin test, and hot-plate test, as well as the in vitro neurolysin inhibition assay, were respectively used to evaluate the antinociceptive activity of agaricoglycerides. The extracted agaricoglycerides inhibited acetic acid-induced abdominal constrictions in mice in a dose-dependent manner (P < .05). Both phases of response to the formalin test were also significantly inhibited (P < .05). The results from the hot-plate test showed that the extract significantly (P < .05) inhibited the reaction time to thermal stimuli at 30, 60, and 90 min after application. In the neurolysin inhibition assay, AMG showed strong activities against neurolysin (IC50 = 100 nM). Our results indicate that if the same effects in humans or higher animals are shown, AMG may have potential applications as a component of analgesic food/ feed and possibly even as a medicine.
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