图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushr.v12.i3.10
pages 227-234

Aqueous Extract of Culinary-Medicinal Royal Sun Mushroom, Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae) Effects on Immunodepression in Mice

Elisabete Fantuzzi
Departamento de Produção Vegetal, Centro de Ciências Agrärias, Universidade Federal do Espirito Santo, ES, Brasil
Lucilene Rezende Anastacio
Programa de Pós- Graduação em Saúde do Adulto, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Jacques Robert Nicoli
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Sergio Oliveira de Paula
Departamento de Biologia Geral, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, MG, Brasil
Rosa Maria Esteves Arantes
Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Sergio Luis Pinto da Matta
Departamento de Biologia Geral, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, MG, Brasil
Maria Cristina Dantas Vanetti
Departamento de Microbiologia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, MG, Brasil

ABSTRACT

Agaricus brasiliensis S. Wasser et al. (=Agaricus blazei Murrill sensu Heinem.) has received attention in folk medicine due to its possible medicinal values. This study evaluated the effects of an A. brasiliensis aqueous extract on weight gain; bacterial translocation; intestinal levels of total sIgA; serum levels of tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and interleukin-10 (IL-10); splenic index; and histology of the ileum, spleen, and liver of mice experimentally immunodepressed with cyclophosphamide. A. brasiliensis aqueous extract was administrated ad libitum and by intragastric gavage in mice aged 6 to 7 weeks, 2 weeks before the first dose of cyclophosphamide and until the 23rd day of the experiment. Experimental immunodepression was confirmed by body-weight loss during the last week of the experiment, reduction of the splenic index, and altered splenic histology. However, Gram-negative bacteria translocation was not observed in the immunodepressed animal groups during the experimental period. Alterations due to immunodepression treatment and cited above were not influenced by oral treatment with A. brasiliensis extract. Similarly, treatment with A. brasiliensis extract did not influence intestinal IgA levels or TNF-α, IFN-γ, and IL-10 levels in serum. Under the conditions used in the present study, alterations obtained by experimental immunodepression in mice were not reduced by oral treatment with A. brasiliensis extract.


Articles with similar content:

Evaluation of Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al., Aqueous Extract in Mice Challenged with Salmonella enterica Serovar Typhimurium
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 3
Elisabete Fantuzzi, Lucilene Rezende Anastacio, Maria Cristina Dantas Vanetti, Rosa Maria Esteves Arantes, Sergio Oliveira de Paula, Jacques Robert Nicoli
Safety Evaluation of an Aqueous Extract of Termitomyces robustus (Agaricomycetes) in Wistar Rats
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 2
Okezie Emmanuel, Victor Chibueze Ude, Ozioma Onyero, Eziuche Amadike Ugbogu, Emmanuel Iroha Akubugwo, Cynthia Ibe, Nduka Ozoji Okomba
A 90-Day Subchronic Toxicity Study of Submerged Mycelial Culture of Cordyceps cicadae (Ascomycetes) in Rats
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 8
Shu-Hsing Yeh, Ting-Wei Lin, Chin-Shuh Chen, Yen-Lien Chen, Chin-Chu Chen, Chia-Feng Kuo
In Vivo Toxicity of the Culturable Marine Cyanobacterium Geitlerinema pseudacutissimum CNP 1019 Extract on Male Swiss Albino Mice (Mus musculus)
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Veerabadhran Maruthanayagam, Manivel Nagarajan, Sundararaman Muthuraman
Hepatoprotective Effects of Aqueous Extract from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) on α-Amanitin−Induced Liver Injury in Mice
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 4
Jinsong Hu, Xin Wu, Jun Zeng, Qiong Liao, Zuohong Chen, Rong Zhou, Ping Zhang