每年出版 12 期
ISSN 打印: 1521-9437
ISSN 在线: 1940-4344
Indexed in
Protective Effect of Ethanol Extracts of the Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes), on the Experimental Middle Cerebral Artery Occlusion/Reperfusion (MCAO/R) Model
摘要
In this study, we investigated the effects of ethanol extracts of Ophiocordyceps sinensis (EEOS) on neuroprotective efficacy in a rat model of focal cerebral ischemia/reperfusion (IR). The effects of EEOS on mortality rate, neurobehavior, grip strength, polymorphonuclear (PMN) cells, interleukin (IL)-1β, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α, intracellular adhesion molecule 1 (ICAM-1), and cyclooxygenase-2 (COX-2) were determined by enzyme-linked immunosorbent assay and immunohistochemistry. The cerebral infarction was examined through tetrazolium chloride staining. EEOS significantly inhibited IR-induced brain production of IL-1β, TNF-α, iNOS, ICAM-1, and COX-2. Moreover, EEOS suppressed infiltration of PMN cells. EEOS caused a significant reduction in the infarct size compared with the middle cerebral artery occlusion group. The study demonstrates the neuroprotective potential of EEOS inhibition of IR through anti-inflammatory activity in a rat model of IR.
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Bai Xue, Tang Yibo, Lin Yan, Zhao Yuqing, Tan Tianyang, Wang Shuyan, Liu Meiqi, Chang Zhenghui, Liu Ying, Liu Zhenquan, Protective effect of Cordyceps sinensis extract on rat brain microvascular endothelial cells injured by oxygen–glucose deprivation, Journal of Traditional Chinese Medical Sciences, 5, 1, 2018. Crossref
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Ferrer Miguel D., Busquets-Cortés Carla, Capó Xavier, Tejada Silvia, Tur Josep A., Pons Antoni, Sureda Antoni, Cyclooxygenase-2 Inhibitors as a Therapeutic Target in Inflammatory Diseases, Current Medicinal Chemistry, 26, 18, 2019. Crossref